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Question 1

Give two ways HCO3- is created in Kidney and one way in which it is e

Answer 1

Breakdown of glutamine to form HCO3- and NH4+ Combining H20 and CO2

Question 2

What are the four cellular responses to acidosis?

Answer 2

– Enhanced H+/Na+ exchange • Full recovery of all filtered HCO3– Enhanced ammonium production in proximal tubule – Increased activity of H+ ATP-ase in distal tubule – Increased capacity to export HCO3 from tubular cells to ECF