deck_1661516 Flashcards
Give the three main parts of the bladder
• Body • Trigone • Neck
Give the histological layers of the bladder wall
MUCOSA • Transitional epithelium • Lamina propria • SubmucosaNOT MUCOSA • Detrusor muscle • Adventiia
What is the body/fundus of the bladder?
• Temporary store of urine
What is the trigone?
• Ureteric orifices and internal urethral orifice are at the angles of a triangle
What is the neck of the bladder?
• Connects the bladder to the urethra
Outline the structure of the detrusor urinae muscle
• Made from a meshwork of muscle fibres in roughly 3 layers ○ Inner longitudinal ○ Middle circular ○ Outer longitundinal
Why does the bladder have three layers of muscle?
• Arrangement of muscle gives the bladder strength regardless of direction it is being stretched in
What is detrusor muscle supplied by?
• Autonomic nervous system, not under voluntary control Spinal nerve supply is bilateral
What is the internal urethral sphincter?
• Continuation of the detrusor muscle and made of smooth muscle • Physiological sphincter at the bladder neck
What is a physiological sphincter?
• A sphincter which is indistinguishable from surrounding tissue at autopsy
What is the primary muscle of continence?
• Internal Urethral Sphincter
What is the external urethral sphincter
• Anatomical sphincter ○ Localised circular muscle thickening to facilitate action
What is the external urethral sphincter derived from?
• Pelvic floor muscles
What type of muscle is the external sphincter?
• Skeletal muscle under somatic, voluntary control • Contracts to constrict urethra and hold in urine
What are the two innervations of the detrusor?
• Parasympathetic • Sympathetic
Outline the parasympathetic innervation of the detrusor
• Pelvic nerve (S2-S4) • Ach - M3 receptorsContraction
Outline the sympathetic innervation of the detrusor?
• Hypogastric nerve (T10-L2) • NA -> B3 receptors • Relaxation
What is the innervation of the internal urethral sphincter?
• Sympathetic • Hypogastric nerve (T10 - L2) • NA -> a1 receptors • Contraction • Parasympathetic • Pelvic nerve
What is the innervation of the external urethral sphincter?
• Somatic • Pudendal nerve (S2-S4) • Spinal motor outflow from Onof’s nucelus of the ventral horn of the spinal cord • Ach -> Nicotinic teceptor • Contraction
What are the four main functions of the nervous system in relation to the bladder?
• Provide sensation of bladder filling and pain • Allow the bladder to relax and accomodate to increasing volumes of urine • To initiate and maintain voiding so bladder empties completely, with minimal residual volume • To provide an integrated regulation of the smooth muscle and skeletal muscle sphincters of the urethra
What prevents retrograde ejaculation in men?
• Prostatic urethra
Give the nerve roots which control urine storage
• L1 & L2
Give the nerve roots which control bladder voiding
S2-S4
What are the two phases of the bladder?
• Emptying • Filling
What occurs in the filling phase?
• The bladder relaxes and accommodates increasing volumes of urine • The urethral sphincters increase their tone to maintain continence
What volume of urine is usually required to cause the urge to urinate?
• >150ml
What is the overall capacity of the urinary bladder?
• 350 - 750ml
Outline the nervous pathway which is activated once bladder has a volume of >400ml and urge to urinate arises
• Brain micturition centres -> Spinal micturition centres -> parasympathetic neurones -> Pelvic nerve -> Contraction of detrusor muscle -> Rise in intravesicular pressure