DAT bio chapter 11.9 excretory system Flashcards
What is excretion
filtering out of metabolic wastes
from the body’s fluids and eliminating them as
urine.
How many kidneys do humans havw
2
Structure of kidney
a cortex (outer portion where blood enters
the kidney), a medulla (middle portion), and a
pelvis (inner portion where filtrate exits the
kidney).
What is a nephron
a single, functional unit of a kidney.
Kidney is made up of thousands of these nephrons
what are four main processes that occur in the
nephron:
- Filtration
- Reabsorption
- Secretion
- Excretion
Why is the excretory system so important?
it helps expels urine and make sure the body retains the water and solutes it needs to survive
Where does filtration occur?
in the cortex at the renal
corpuscle,.
Renal corpuscle contains what
consists of the glomerulus and
the Bowman’s capsule.
Filtration path way (look at the pictures
Blood enters from the
afferent arteriole into the glomerulus, which acts
as a sieve. Podocytes from the Bowman’s
capsule surround the glomerulus to form
fenestrations that allow small substances (water
and solutes) to be filtered into the Bowman’s
capsule while larger substances (proteins and
blood cells) remain in the blood. The glomerulus
exits the Bowman’s capsule via the efferent
arteriole, which goes on to form the peritubular
capillaries.
How does Reabsorption happen in nephron?
The loop of Henle descends into the medulla
and has selective permeability. It is surrounded
by the vasa recta (capillaries running parallel to
the loop of Henle). Water is reabsorbed into the
blood as the filtrate travels down the
descending limb (filtrate becomes more
concentrated), and solutes are reabsorbed as the
filtrate travels up the ascending limb (filtrate
becomes less concentrated).
What is secretion
transfer of solutions from the
blood vasculature directly into the nephron tubule
filtrate.
where does secretion happen?
distal convoluted
tubule and the proximal convoluted tubule.
How does excretion happen?
filtrate (now urine) travels from the
nephrons to the collecting duct, which leads to
the renal pelvis and then to the ureter.
The ureter connects the kidney to the bladder,
where urine is stored. When the signal is received,
urine is excreted from the bladder and the body
via the urethra.
Parathyroid Hormone (PTH)
more blood calcium. Stimulates calcium reabsorption in the tubules, and indirect stimulation of osteoclasts (more bone breakdown)
Calcitonin (hormone)
less blood calcium (calcitonin
tones down calcium). Inhibits calcium
reabsorption in the tubules, inhibits
osteoclasts (less bone breakdown)
Renin Angiotensin Aldosterone
System:
Juxtaglomerular cells
renin
Juxtaglomerular cells can detect
changes in blood pressure and sodium
levels. When blood pressure or blood
sodium is low, these cells release renin.
Renin is an enzyme which acts on
angiotensinogen to activate it to the
form angiotensin I. Another enzyme
called Angiotensin Converting Enzyme
(ACE) acts on angiotensin I to convert it to
angiotensin II. Angiotensin II is the active
hormone.
Angiotensin II effects on the body
It stimulates additional aldosterone release from the adrenal gland cortex (so aldosterone levels increase). ● It increases Na+ reabsorption from the proximal tubule (and water will follow the salt). ● It is a potent systemic vasoconstrictor, causing vessels to constrict and thereby increasing total peripheral resistance (TPR). ● It makes the individual more thirsty: so they drink more and increase their blood liquid volume (increasing TPR).
Aldosterone (hormone)
Is what
produced by what
function
is a mineralocorticoid
produced by the adrenal cortex. It
increases salt and water reabsorption and
potassium secretion in the distal tubules
and collecting ducts
Antidiuretic hormone
Is what
produced by what
function
vasopressin Hormone (aka ADH or vasopressin). Released from the posterior pituitary upon stimulation from the hypothalamus. Causes aquaporins to insert into the collecting duct of the nephron and increases water reabsorption
Atrial natriuretic peptide
Is what
produced by what
function
produced by atrial cells in response to atria
distension by increased blood volume and
pressure. ANP will reduce the blood
volume and blood pressure. It
accomplishes this by: Increasing the
glomerular filtration rate (GFR); decreasing
sodium reabsorption and increasing
sodium excretion; inhibiting renin and the
renin-angiotensin-aldosterone system
(RAAS).
Together, the glomerulus and the bowmans capsule is known as
Renal corpuscle