Dani - immunopathology II

Question 1

___ ___ ___: autoimmune disease of CT that involves mutliple systems

Answer 1

systemic lupus erythematosus

Question 2

SLE = ___ ___ ___

Answer 2

systemic lupus erythematosus

Question 3

SLE occurs __:__

Answer 3

1:2500

Question 4

ratio of females to males for SLE

Answer 4

9:1

Question 5

onset of SLE occurs __-___

Answer 5

20-40

Question 6

2 genetic factors for SLE

• ____ incidence
• ___-___ and ____

Answer 6

familial

HLA-DR2; DR3

Question 7

SLE immunological factors

• deficiency of ___ T-Cells
• hyperactive ___ T-Cells
• abnormal __-Cells

Answer 7

suppressor
helper
B

Question 8

SLE is drug induced by 2 types of drugs

Answer 8

hydralazine

procainamide

Question 9

SLE happens in ___ infections

Answer 9

viral

Question 10

SLE is exacerbated by ___

Answer 10

pregnancy

Question 11

SLE
- autoimmune disease: ___ antibodies against several nuclear antigens –> react with nuclei of damaged cells (cannot penetrate ___ cells)

Answer 11

antinuclear

intact

Question 12

SLE

- activation of complement –> inflammatory lesions (type ___ hypersensitivity)

Answer 12

III

Question 13

LE bodies =

Answer 13

fragmented nuclei

Question 14

LE cells

Answer 14

macrophages engulfing bodies

Question 15

blood vessels in SLE

• acute ___ of small arteries and arterioles due to deposition of immune complexes
• __ and ___ deposits within vessel wall
• later, ___ thickening with luminal narrowing
• perivascular ___ infilterate

Answer 15

vasculitis
necrosis; fibrinoid
fibrous
lymphocytic

Question 16

3 effects of SLE on the heart

Answer 16

pericarditis
myocarditis
endocarditis

Question 17

endocarditis in SLE = ___-____

Answer 17

libman-sacks

Question 18

libman-sacks:

- multiple, small, sterile, flat vegetations, detachable –> ___

Answer 18

embolization

Question 19

kidneys remain normal in ____ patients with SLE

Answer 19

few

Question 20

kidney in SLE

-_____ glomerulonephritis: increased cellularity of mesangial matrix

Answer 20

mesangial

Question 21

kidney in SLE
- ____ ____ glomerulonephritis: hypercellularity, but no all focal glomeruli, due to proliferation of endothelial and mesangial cells; present with hematuria, proteinuria, and mild renal insufficiency

Answer 21

focal proliferative

Question 22

kidney is SLE
- _____ ____ glomerulonephritis: most serious, all glomeruli involved; hematuria, proteinuria, hypertension and renal insufficiency

Answer 22

diffuse proliferative

Question 23

kidney in SLE

- ___ glomerulonephritis: thickening of capillary wall –> massive proteinuria

Answer 23

membranous

Question 24

glomerulus with thickened pink capillary loops = ____ ____

Answer 24

wire loops

Question 25

skin in SLE

- deposition of immune complexes along ___-___ junction

Answer 25

dermo-epidermal

Question 26

skin in SLE

- erythema, maculopapular rash: malar regions of face and bridge of nose = ___ rash

Answer 26

butterfly

Question 27

joints in SLE

- ____ is the most common presenting symptom

Answer 27

arthritis

Question 28

CNS in SLE

- vasculitis –> 3 things

Answer 28

infarction
ischemia
hemorrhages

Question 29

serosal cavities in SLE

- inflammation with ___ effusion or ___ exudation in acute cases to ___ opacification in chronic cases

Answer 29

serous
fibrinous
fibrous

Question 30

diagnosis of SLE

• ___ ___ in the serus
• presence of ___ cells

Answer 30

antinuclear; antibodies

LE

Question 31

prognosis of SLE
- chronic course with repeated ___ and ___
death mostly due to ___ ___

Answer 31

exacerbations; remissions

renal failure

Question 32

___ cells: nuclear debris ingested by blood neutrophils

Answer 32

LE