Dani - immunologic deficiency Flashcards
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___ immunologic deficiency: genetic, present at birth
primary
___ immunologic deficiency: acquired
secondary
congenital agammaglobulinemia:
- __ linked recessive disorder
- absence of ___ lymphocytes
X
B
congenital agammaglobunlinemia (aka ____)
bruton’s
absence of B lymphocytes in Bruton’s
- normal total lymphocyte count
- serum immunoglobulins are markely ___ or __
- deficient ___ immunity: reccurrent pyogenic infections 5-6 mo after birth
decreased; absent
humoral
congenital thymic hypoplasia (aka ____ syndrome)
DiGeorge’s
DiGeorge’s syndrome
- development defect f the ___ and ___ pharyngeal pouches –> absence of the ___ and ___ glands
3rd; 4th
thymus; parathyroid
DiGeorge’s syndrome
- lack of __ lymphocytes
T
lack of T lymphocytes in DiGeorge’s syndrome
- __ total lymphocyte count in blood
- ___ CMI –> severe viral, fungal, protozoal infections in infancy
decreased
deficient
DiGeorge’s syndrome
- ___ and ___
hypocalcemia
tetany
severe combine immunodeficiency
- aka ___
SCID
SCID
- __ linked or ___ recessive disorder
X
autosomal
SCID
- defect in lymphoid stem cells –> failure of development of both __ and ___ lymphocytes
B
T
SCID
- deficient ___-___ and __ immune responses
cell-mediated
humoral
dysgammaglobulinemia
- most common ___ immunodeficiency
primary
