Dani - ch 9 Flashcards
cardiac and skeletal muscle both fibers have a ___ appearance
striated
cardiac and skeletal muscle both rely on the opening of ___ ___ channels to initiate the action potential for contraction
fast sodium
cardiac and skeletal muscle contraction both are based on ____ filaments
sliding
cardiac muscle is most similar to ___ __ fibers
type I
Type I fibers are ___ twitch fibers, have more ___, and have ____ conducting neurons
slow
mitochondria
slow
cardiac muscle is ___ while skeletal is ____
involuntary
voluntary
cardiac fibers are interconnected by ___ disks
intercalated
the heart is divided into two functional ____ which allows the atria to contract before the ventricles
synctia
cardiac muscle has ___ ___ channels that must open to achieve action potentials
slow calcium
slow calcium channels of cardiac muscles cause a ____ in the action potential
plateau
duration of cardiac contraction is ~___ times longer for cardiac muscle than skeletal muscle
10
intercalated disks serve to fuse the cells together to form ___ ___ allowing for rapid diffusion of ions
gap junctions
gap junctions allow the action potential to travel rapidly from one cardiac ___ to the next
myoctye
at rest, the intracellular surface is ~___mV and if threshold is reached, it continues to ____mV at the peak of the AP
-85
20
for cardiac muscle, once the AP spikes at about ____mV, it begins to repolarize but ____ before it completely repolarizes
20
plateaus
the plateau is the reason why cardiac contraction is significantly ____ than skeletal
longer
phase 0 of AP
- opening of ___ ____ channels –> rapid _____
fast sodium
depolarization
phase 1 of AP
- at peak, repolarization begins = short ____ interval betweek peak and beginning of plateau
downward
phase 2 of AP
- opening of ___ ___ channels and continues sodium influx = ____
slow calcium
plateau
phase 2 of AP
- when slow calcium channels open, decrease outflux of sodium –> ____
plateau
phase 3 of AP
- ___ ____ channels close so increase of potassium outflow –> rapid ____
slow calcium
repolarization
___ ____ ___: the interval during the AP when a “normal” electrical impulse cannot re-excite the already excited area
absolute refractory period
___ ___ ___: a stronger than normal stimulus can re-excite the area
relative refractory period
there is no ___ ___ in cardiac muscle from premature contractions
wave summation
unlike skeletal myofibrils, cardiac myocytes rely on ___ ____ for contraction to occur
extracellular calcium
extracellular calcium enter the cardiac __ ____ and then enter the ___ via voltage gated calcium channels
t-tubules
sarcoplam
the influx of calcium activates the ____ recpetors on the SR membrane which triggers the SR to release ____
ryanodine
calcium
at the end of contraction, calcium is pumped back into the SR via the ___-____ pump
calcium-ATPase
calcium exits the sarcoplasm via the ___-___ exchanger
sodium-calcium
the sodium entering through the sodium-calcium pump is transported back out of the cell via ____-___ exchange pump
sodium-potassium
sodium-potassium pump
- __ sodium out
- __ potassium in
3
2
duration of atrial contraction
.2 sec
duration of ventricular contraction
.3sec
____ ____: series of events that occur from the onset of one heart beat to the beginning of the next heart beat
cardiac cycle
cardiac cycle is often defined as __ wave to __ wave
P
P
calculate total duration of a single cardiac cycle as a ___ of ___ ____
reciprocal
heart rate
RHR = __/___
1/HR
duration of systole at rest is about __% of total duration
40
when HR increases, the total duration of cardiac cycle decreases but the relative time spent in ventricular systole actually ___
increases