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Immunology > Cytokines , receptors and signaling > Flashcards

Cytokines , receptors and signaling Flashcards

1
Q

source of TNF

A

macrophages, T cells

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2
Q

Target of TNF

A

enothelia, epitherlia, neutrophils, hypothalamus, liver, muscle

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3
Q

Function of TNF

A

Activation (inflammation) and oxicdative burst and fever

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4
Q

Activation (inflammation) and oxicdative burst and fever caused by

A

TNF

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5
Q

IL-1 made by

A

Macrophages and endothelial cells

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6
Q

IL-1 targets

A

enodothelia and hypothalamus, liver

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7
Q

IL-1 causes

A

activation of inflammation and fever

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8
Q

IL-1 in the liver cauess

A

acute phase protein synthesis

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9
Q

IL-6 made by in

A

macrophages, endothelial cells and T cells

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10
Q

IL-6 targets

A

Liver and B cells

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11
Q

IL-6 causes

A

acute phase protein synt in the liver and poliferation of anitbody producing B cells

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12
Q

IL12 made by

A

DCs and macrophages

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13
Q

IL12 target

A

T cells

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14
Q

IL12 function

A

Increase IFN-gamma secreation, increase cytotoxic activity, Th1 differentiation

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15
Q

IL23 makde by

A

DCs and marcorphages

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16
Q

IL-23 targets

A

T cells

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17
Q

IL-23 promotes

A

Th17 differentiation

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18
Q

IL8 and other chemokines makde by

A

DCs and endothelia and T cells

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19
Q

IL-8 and other chemokines targe

A

leukocytes

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20
Q

IL8 funciton

A

PMN chemotaxis, leukocyte migration, DC lymph node migration

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21
Q

IFN gamma and IFN betta are examples of

A

antiviral cytokines

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22
Q

INF alpha made by

A

DCs

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23
Q

INF betta made by

A

fibroblasts

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24
Q

INF alpha tagets

A

all cells

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25
Q

INF alpha causes

A

anitiviarl immunity, increase class I MHC and activates NK cells

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26
Q

What ativates NK cells

A

INFalpha

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27
Q

IFN gamma (helper) made by

A

TH1 cells

28
Q

INF gamma targets

A

macrophages and B cells

29
Q

INF gamma

A

activates macrophage, isotype switching in B cells to IgG

30
Q

IL4, IL5, IL13 make by

A

Th2 cells

31
Q

IL4/5/13 target

A

B cells

32
Q

IL4/5/13 cause

A

isotype switch to IgE

33
Q

IL17 is from

A

TH17

34
Q

IL17 target

A

PMNS and epithelia

35
Q

IL17 caues

A

activation /mitogen for PMNs and increases antimicrobial peptides

36
Q

TGFbetta comes from

A

epithelia, NK cells, Tregs, fibroblats, endothelia, others

37
Q

TGF betta targets

A

T cells and B cells

38
Q

TGF betta acts by

A

suppressing Th1 and Th2 devo, promotes Th17 differentiation and increaes B cell IgA isotype switching

39
Q

What suprreses Th1 and Th2 devo

A

TGF betta

40
Q

what promotes Th17 differentiation

A

TGFbetta

41
Q

what increas B cell IgA isotype swithc

A

TGFbetta

42
Q

what increases anitviarl immunity

A

INFgamma/betta

43
Q

What activates NK cells

A

INFgamma

44
Q

What couases increase in IFNgamma secreation and Th1 differentiation

A

IL12

45
Q

What two things act on hypothalamus to cause fever

A

IL1, and TNF

46
Q

causes isotype switching in B cells to IgG

A

INFgamma acting through Th1

47
Q

IL10 source is

A

macrophages, DC, Th2 cells

48
Q

IL 10 targets

A

macrophates, DCs and T cells

49
Q

IL 10 functions to

A

inhibit IL12 produciton, reduce MHC class II and inhibit co-stim molecule expression

50
Q

what inhibits IL12 produciton

A

IL10

51
Q

What reduces MHC class II

A

IL10

52
Q

What ihibits co-stim molecule expression

A

IL10

53
Q

IL 2 source

A

Activated T cell

54
Q

IL2 targets

A

autocrine activated T cells

55
Q

IL2 function:

A

mitogen for activat mature niave T cells

56
Q

IL 7 source

A

bone marrow stromal

57
Q

protects body against bacteria and fungi

A

Th17

58
Q

IL 7 targets

A

Immature T and B lymphocytes

59
Q

IL 7 funciton

A

mitogen for devoi’ng immautre lymphocytes

60
Q

IL15 and IL18 source

A

marcrophages

61
Q

IL 15 and IL 18 target

A

NK cells

62
Q

IL15 and IL18 function to

A

be a mitogen for NKcells to push for IFNgamma production.

63
Q

G-CSF and GM-CSF source

A

Macros adn T cells

64
Q

Target for G-CSF and GM-CSF

A

immature myeloid cells

65
Q

function of G-CSF and FM CSF

A

mitogen for myloid progenitor cells, immune suppresion

Immunology (12 decks)

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