Cytokines Flashcards
IL-1 (alpha, beta)
stimulates IL-2 receptor emergence in T cells
Enhances B cell activation
Induces fever, acute phase reactants, and IL-6
IL-2
T cell growth factor
Activates NK and B cells
IL-3
Stimulates hematopoiesis
IL-4
Stimulates B cell synthesis of IgE
Down regulates IFN-gamma
IL-5
Stimulates growth and differentiation of eosinophils
B cell growth factor
Enhances IgA synthesis
IL-6
Induces acute phase reactants, fever, and late B cell differentiation
IL-7
Stimulates pre-B and pre-T cells
IL-8
Chemotactic factor for neutrophils and T cells
IL-9
Cell mitogen
IL-10
Inhibits IFN-gamma synthesis by TH1 cells
Suppresses other cytokine synthesis
IL-11
Stimulates hematopoiesis
Enhances acute phase protein synthesis
IL-12
Promotes TH1 differentiation and IFN-gamma synthesis
Stimulates NK cells and CD8+ T cells to ctolysis
Acts synergistically with IL-2
IL-13
Inhibits inflammatory cytokines
IL-15
T cell mitogen
Enhances growth of intestinal epithlium
IL-16
Increases class II MHC, chomtaxis, and CD4+ T cell cytokines Decreases antigen induced proliferation
