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Immunology Test 1 > 5 T Cell Diversity and Development > Flashcards

5 T Cell Diversity and Development Flashcards

1
Q

Where is a T cell made?

A

Bone Marrow

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2
Q

Where does a T cell mature?

A

Thymus

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3
Q

Where does a T cell live?

A

Secondary Lymph

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4
Q

What does a T cell derive from?

A

Common lymphoid precursor

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5
Q

What type of single antigen is recognized by a T cell?

A

peptide antigen in context with MHC

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6
Q

What cells does a T cell help activate?

A

Macrophage

CD4 Helper T cell

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7
Q

What are the 2 types of T cell lineage TCRs?

A

AB and yD

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8
Q

What is different about AB T cells?

A

Thymic development
Peptide recognized
MHC restricted

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9
Q

What is different about yD T cells?

A

Mucosal epithelium location
Lipid recognized
Non thymic development
Non-MHC restricted

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10
Q

What do CD3 surface markers do?

A

Signal transduction

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11
Q

What relies on CD3?

A

T cell activation

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12
Q

What is an ITAMs?

A

immunoreceptor tyrosine-based activation motifs in CD3 TCRs

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13
Q

What are CD4 and CD8?

A

Coreceptors for TCRs

All mature T cells have one or the other

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14
Q

What are structural differences between CD4 and CD8?

A

CD4 is a single chain

CD8 is a heterodimer

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15
Q

What MHC class does CD4 recognize?

A

MHC II

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16
Q

What MHC class does CD8 recognize

A

MHC I

17
Q

What antigen type is the MHC II pathway used for?

A

Extracellular pathogens

18
Q

What antigen type is the MHC I pathway used for?

A

Intracellular pathogens

19
Q

What is CD28 used for?

A

Costimulation of T cells

Binds B7 molecules from APCs

20
Q

What is Fas ligand used for?

A

Apoptotic pathway

21
Q

What is the meta organization of the thymus?

A

Cortex

Medullary region

22
Q

Where does positive T cell selection occur?

A

Thymus cortex

23
Q

Where does negative T cell selection occur?

A

Medullary region

Hassal’s corpuscle

24
Q

What is the first step in T cell maturation in the thymus?

A

MHC is presented by cortical cells

25
Q

What is the second step in T cell maturation in the thymus?

A

Somatic recombination

26
Q

What is the overview of T cell maturation?

A

Somatic recombination
Positive selection
Negative selection

27
Q

What is the first chain of the TCR to begin adapting to maturation signals?

A

Beta chain genes

28
Q

What happens in T cell maturation after AB chain recombination?

A

Expression of CD3, then CD4 aaaand CD8

29
Q

When CD4/8 is produced on T cells, what occurs?

A

Positive selection of MHC I/II in the cortex

30
Q

What is downregulated as the T cell moves into the medullary region?

A

The unused CD4/8

31
Q

What is destroyed in the medullary region?

A

Self recognizing T cells

32
Q

How does a T cell become a yD TCR?

A

If y or D are expressed first

33
Q

How does a T cell become a AB TCR?

A
  1. B chain expressed
  2. Invariant chain (pTalpha) transcribed and binds
  3. Pre-T cell receptor combines with the CD3 complex
  4. AB TCR rearrangement (full A chain made)
  5. CD4/8 production
  6. CD4/8 selection
  7. Migration to 2* lymph
34
Q

What occurs in alpha chain gene recombination ?

A

Random

  1. VJ region brought together
  2. Transription
  3. C region spliced to be proximal
  4. Translation
35
Q

What occurs in B chain gene recombination?

A

Random

  1. VDJ region joined
  2. Transcription
  3. C region spliced to be proximal
  4. Translation
36
Q

What T cell tumor would express CD34?

A

T cell tumor of Bone Marrow stem cell origin

37
Q

What T cell tumor would express CD10,19, 20?

A

T cell tumor of Thymus progenitor cell origin

38
Q

What T cell tumor would express CD1?

A

T cell tumor of Thymus developing cell origin

39
Q

What T cell tumor would express CD3, CD4/8, or TCRs?

A

T cell tumor of peripheral origin from mature T cell

Immunology Test 1 (12 decks)

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