4 MHC

Question 1

How many chains are in the Class I MHC structure and what are they called?

Answer 1

Alpha
Beta2 Microglobulin (not in MHC gene)

Question 2

What does the active site of MHC I look like?

Answer 2

Cleft closed at both ends

Question 3

What does the active site of MHC II look like?

Answer 3

Cleft open at both ends

Question 4

What is the range of peptide size for MHC class I?

Answer 4

8-10

Question 5

What is the range of peptide size for MHC II?

Answer 5

13+

More promiscuous and larger antigens bound

Question 6

What route within the cell produces MHC I antigen presentation?

Answer 6

Cytosolic

Proteosome

Question 7

What route within the cell presents MHC II antigen presentation?

Answer 7

Endosome
MHC: 
    1. Invariant chain
    2. Clip protein portion
    3. HLA-DM clip removal 
    4. antigen binding to site

Question 8

What cell recognizes MHC I?

Answer 8

CD8+ T Cells

Question 9

What do CD8+ T cells cells do?

Answer 9

Kill infected cell

Question 10

What cell recognizes MHC II?

Answer 10

CD4 T cell

Question 11

What do CD4+ T cells do?

Answer 11

Help orchestrat B cell activation “helper T cell”

Question 12

What cells are MHC II found on?

Answer 12

APCs

Question 13

Where do MHC II help in T cell maturation?

Answer 13

Cortex of thymus

Question 14

What do MHCI presentations typically mean?

Answer 14

Virus infection!

Question 15

How many alleles do MHC I genes have?

Answer 15

3: ABC

Question 16

How many alleles to MHC II genes have?

Answer 16

3: DP, DQ, DR

Question 17

What is the most variable MHC II allele?

Answer 17

DR, has 2 loci

Question 18

How does the polymorphism of MHC genes affect immunity?

Answer 18

Variety of alleles allows variety of response, increasing immunity response potential