Cytochrome P450 System

Question 1

Inducers

Answer 1

“Chronic alcoholic Mona steals phen-phen and never refuses greasy carbs”: chronic alcoholism, modafinil, St. John’s wort, phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carbamazepine

Question 2

Substrates

Answer 2

“Always, always, always, always think when starting others”: anti-epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs

Question 3

Inhibitors

Answer 3

“A cute gentleman sipped iced grapefruit juice quickly and kept munching on soft cinnamon rolls”: acute alcohol abuse (opposite of chronic alcohol abuse), gemfibrozil, ciprofloxacin, isoniazid, grapefruit juice, quinidine, amiodarone, ketoconazole, macrolides, sulfonamides, cimetidine, ritonavir