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Dermatology Board Prep > DERM (18) Skin Growths > Cutaneous Metastases > Flashcards

Cutaneous Metastases Flashcards

1
Q

What are the most common cutaneous metastases in women and men?

A

women: breast and melanoma
men: melanoma, head & neck, lung, colon

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2
Q

What is the most common clinical presentation of cutaneous metastases?

A

Firm, painless, erythematous nodule(s)

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3
Q

What are the most common cancers on the scalp in men and women?

A
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4
Q

Most common metastases on the abdomen in men and women?

A

Men: Colon, lung, stomach

Woman: Colon, ovary, breast

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5
Q

What are the most common tumors that the Sister Mary Joseph nodule represent?

A

Gastric cancer, colon, ovarian, or pancreatic cancers

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6
Q

What can be the different cutaneous presentations of cutaneous metastases from breast cancer?

A

Papulonodules, patches of erythema, woody induration w/ peau d’ orange

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7
Q

What is the most common presentation of cutaneous metastasis?

A

Dermal or subcutaneous nodules (can be miliary in size or large, multiple or small)

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8
Q

What is the histology of dermal or subcutaneous cutaneous metastases?

A

Tumor cells infiltrating among collagen bundles or replacing dermis; grenz zone often present

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9
Q

What is the presentation of inflammatory carcinoma (carcinoma erysipeloides)?

A

Erythematous patch with spreading border; resembles erysipelas

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10
Q

What cancers are most often represented by inflammatory carcinoma (carcinoma erysipeloides)?

A

Breast>> lung, ovary, prostate, GI, others

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11
Q

What is the histology of inflammatory carcinoma (carcinoma erysipeloides)?

A

Tumor cells in dilated lymphatic vessels

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12
Q

What is cutaneous metastasis en cuirasse?

A

Morpheaform or sclerodermoid, depending upon extent can be indurated with peau d’orange appearance

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13
Q

What cancers are represented by cutaneous metastasis en cuirasse?

A

Breast>>lung, GI, kindey, others

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14
Q

What is the histology of cutaneous metastasis en cuirasse?

A

Fibrosis with infiltrating tumor cells

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15
Q

What is the clinical appearance of carcinoma telangiectodes?

A
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16
Q

What cancer is usually represented by carcinoma telangiectodes?

A

Breast

17
Q

What is the histology of carcinoma telangiectodes?

A

Tumor cells within superficial blood vessels and RBC sludging

18
Q

What is the clinical appearance of Paget’s disease of the breast?

A
19
Q

What is the histology of Paget’s disease of the breast?

A

large, atypical epithelial cells with abundant pale cytoplasm arranged in solitary units and small nests within all layers of the epidermis

20
Q

What is the clinical appearance of alopecia neoplastica?

A

Nodules or plaques on the scalp in association with alopecia

21
Q

What is the clinical appearance of alopecia neoplastica?

A

Cords of tumor cells between collagen bundles

22
Q

What tumors are represented by alopecia neoplastica?

A
23
Q

What is the clinical of pyogenic granuloma-like cutaneous metastasis?

A

Rapidly growing nodule resembling a vascular tumor (particular a pyogenic granuloma)

24
Q

What is the histology of pyogenic granuloma-like cutaneous metastasis?

A

Neoplastic cells in cords and lobules admixed with prominent hemorrhage and “pseudovascular” spaces

25
Q

What tumors are most often involved in pyogenic granuloma-like cutaneous metastasis?

A

Renal clear cell carcinoma, hepatocellular carcinoma > others

26
Q

What stains are important for renal cell cutaneous carcinomas?

A

CD10, PAX-8

27
Q

What is one key IHC stain for colon cancer?

A
28
Q

Histology of cutaneous metastasis for thyroid cancer?

A
29
Q

What important stains should be done initially for a cutaneous metastasis?

A

CD45/CD43 (hematopoietic lineage), CD34/podoplanin/CD31 (Vascular neoplasms), S100/MITF/HMB45/SOX-10/Melan-A (Melanoma),

Keratins, if + –> C5/6, p40/p64 if + –> CK7 –> if + then CK20 (distinguishes bladder/urothelial if + or breast/lung/ovarian/endometrial/pancreas if -. If CK7 is negative –> CK20 still –> if + colorectal/gastric and if negative = prostate/renal

30
Q
A

DERM (18) Skin Growths (17 decks)

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