Cushing Syndrome - Primary Cortical Hyperplasia

Question 1

Types - 2

Answer 1

Macro nodular

Micro nodular

Question 2

ACTH dependent?

Answer 2

nop

Question 3

Macro nodular - Pathophisiology

Answer 3

Cells acquire receptors to hormones other then ACTH leading to nodular hyperplasia

Question 4

Macro nodular - why? - 3

Answer 4

1. Mostly sporadic
2. can be related to GNAS mutation
3. PRKAR1A mutation

Question 5

Macro nodular - Morphology

Answer 5

Macro - large (3cm) nodules of fat (yellow)

Micro - some parts are hyperplastic, others are not…

Question 6

Macro nodular - why?

Answer 6

Genetic - ex. - PRKAR1A

Question 7

Micro nodular - Morphology

Answer 7

Macro - small nodules (3 mm), thin cortex.

Micro - Brown areas, lypophoscin.