Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Endocrinology > Cushing's Syndrome > Flashcards

Cushing's Syndrome Flashcards

1
Q

What are the three criteria for Cushing’s Syndrome?

A

Chronic glucocorticoid excess, Loss of normal HPA axis feedback mechanisms, Loss of circadian rhythm of cortisol secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are ACTH dependent causes of CS?

A

Cushing’s disease (pituitary adenoma), Ectopic ACTH secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are 2 ACTH independent causes of CS?

A

Iatrogenic (Steroids), Adrenal adenoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In what type of Cushing’s is ACTH raised?

A

ACTH dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does ACTH stand for?

A

Adrenocorticotropic hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does ACTH dependent Cushing’s occur?

A

Increased ACTH leads to more cortisol and androgens being produced by the adrenal cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is cortisol?

A

Cortisol is a glucocorticoid that affects carbohydrate, lipid and protein metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are androgens?

A

Androgens are converted into testosterone and dihydrotestosterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How do steroids cause CS?

A

Steroids contain glucocorticoids that can mimic the effects of cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do adrenal adenomas/carcinomas cause CS?

A

They can secrete cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are some key presentations of CS?

A

Central obesity, plethoric complexion, weight gain, purple abdominal striae, mood change, moon face, proximal muscle weakness, gastric ulcers, osteoporosis, hirsutism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What can be an issue with testing random plasma cortisol?

A

Illness, time of day, and stress can influence results

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the first line investigation?

A

Random plasma cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What would the results of a 48h dexamethasone suppression test?

A

Failure to suppress in CS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What do you do if plasma ACTH is untetectable?

A

Look for an adrenal tumour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do you do if ACTH is detectable?

A

High dose suppression test to distinguish between ectopic and pituitary

17
Q

What do you do if cortisol responds to manipulation?

A

Image the pituitary

18
Q

What do you do if cortisol doesn’t respond to manipulation?

A

Look for source of ectopic ACTH production

19
Q

How do you manage iatrogenic CS?

A

Stop medication if possible

20
Q

How do you manage adrenal adenoma CS?

A

Adrenalectomy

21
Q

How do you manage ectopic ACTH production CS?

A

Surgery if tumour is located and hasn’t spread

22
Q

What are some complications of CS?

A

CVD, HTN, DM, Osteoporosis

23
Q

What would the results of a 48h high-dose dexamethasone suppression test be?

A

Pituitary causes are suppressed, other causes have no or part suppression

24
Q

What do you do if random plasma cortisol is high?

A

Overnight dexamethasone suppression test and urinary free cortisol

25
Q

What do you do if overnight dexamethasone suppression test and urinary free cortisol is positve?

A

Test plasma ACTH

Endocrinology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions