Cushing's Disease Flashcards
1
Q
Is CD ACTH dependent or independent?
A
ACTH Dependent
2
Q
What is CD?
A
ACTH-secreting pituitary adenoma
3
Q
What investigations can indicate that the cause of CS is CD?
A
Low dose dexamethasone shows no cortisol suppression but high dose dexamethasone does show cortisol suppression
4
Q
How do you manage CD?
A
Transsphenoidal surgical resection
5
Q
When would you perform a bilateral adrenalectomy?
A
If the source is unlocatable or there is recurrence post op
6
Q
What is a possible complication if you perform a bilateral adrenalectomy?
A
Nelson’s Syndrome
7
Q
What is Nelson’s syndrome?
A
ACTH becomes very raised because the pituitary is enlarging due to no negative feedback from adrenal glands
8
Q
What is Nelson’s syndrome characterised by?
A
An increase in skin pigmentation
