Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical Sciences and Investigative Medicine > CSIM 1.24 - T-cells 1 > Flashcards

CSIM 1.24 - T-cells 1 Flashcards

1
Q

What is the sign cluster differentiation of T-cells?

A

CD3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the sign cluster differentiation of B-cells?

A

CD19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where do T-cells arise and differentiate and mature?

A

Arise in bone marrow

Differentiate and mature in the thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the basic function of CD4 T-helper 1 cells and which cytokines are secreted?

A 
Activates macrophages (cell-mediated immunity)
Secretes IL-2 and IFN-Y
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the basic function of CD4 T-helper 2 cells and which cytokines are secreted?

A

Helps B-cells in class-switching (humoral immunity)

Secretes IL-4 and IL-5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the basic function of CD4 T-helper 17 cells and which cytokines are secreted?

A

Attracts nuetrophils and maintains mucosal integrity

Secretes IL-17 and IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the basic function of CD8 T-cytotoxic cells?

A 
Interacts with MHC class 1 molecules
Directly kills virally infected cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the basic function of T-regulatory cells?

A

Controls the immune response after activation

Prevents autoimmune damage by secreting FOXP3+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

B-cell antibodies (receptors) have heavy and light chains, what is the T-cell receptor equivalent?

A 
Beta chain (VDJ gene segments present)
alpha chain (VJ gene segments present)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is T-cell receptor diversity established?

A

Junctional diversity - via imprecise joining of VDJ gene segments and random addition of nucleotides at junction by terminal transferase
NO somatic hypermuation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In the cytoplasmic domain name the protein complexes responsible for facilitating intracellular signalling transduction?

A

Immuno-receptor tyrosine-based activation motifs (ITAMs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Name five ANTI-inflammatory cytokines?

A 
IL-4
IL-10
IL-11
IL-13
TGF-B
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name four PRO-inflammatory cytokines?

A

IL-1
IL-6
TNF-a
IL-17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

On which chromosome is the MHC (membrane glycoprotein) encoded on?

A

Chromosome 6 - (HLA genes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Defect of HLA-27 is known as what?

A

Ankylosing Spondylitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

In which body regions is MHC class 1 expressed?

A 
T-cells
B-cells
Macrophage
Dendritic cells
Thymic corticle epithelial cells
ALL other nucleated cells
17
Q

In which body regions is MHC class 2 expressed?

A

ACTIVATED T-cells
B-cells
Macrophage
Thymic corticle epithelial cells

18
Q

Describe the structure of MHC 1 and 2 molecules?

A

alpha (heavy) chain - 1/2/3 - Ag binding cleft between 1 and 2
Beta (light) chain
MHC class 1 - 8 to 10 amino acids long
MHC class 2 - 15 to 17 amino acids long

Clinical Sciences and Investigative Medicine (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions