CSIM 1.21 - Herpes Virus 2

Question 1

Where does latency reside for cytolomeglovirus infections?

Answer 1

Lymphocytes

Question 2

What are the symptoms with a primary infection of cytolomeglovirus?

Answer 2

Asymptomatic

Question 3

What are the complications surrounding cytolomeglovirus?

Answer 3

Congenital CMV - passed vertically in utero

Developmental delay and hearing loss

Question 4

Describe cytolomeglovirus infection risks following transplantation?

Answer 4

Solid organ transplant = Increased risk if donor is positive (+) and recipient is negative (-) = causes primary infection in recipient
Stem cell transplant = Increased risk if donor is negative (-) and recipient is positive (+) as recipient has CMV virus but donor T-cells don’t know how to deal with them

Question 5

Where does latency reside for epstein-barr virus?

Answer 5

B-cells

Question 6

Describe the epidemiology of epstein barr virus?

Answer 6

95% of people will have it by 40 years old

Most common in adolescent

Question 7

What symptoms arise from infection with epstein barr virus?

Answer 7

Infectious mononucleolus - glandular fever
Fever
Lymphadenopathy
Sore throat

Question 8

What are the complications of epstein barr virus infections?

Answer 8

Burkitt’s lymphoma (very malignant B-cell lymphoma)
PTLD
Hodgekin’s lymphoma

Question 9

Describe the common symptoms and complications associated with HHV 6 and 7?

Answer 9

Roseola infantum

Complications = febrile convulsions (primary infection) and encephalitis

Question 10

Which cancer is commonly associated with HHV-8?

Answer 10

Kaposi’s sarcoma