CPT2: Right drug for right bug Flashcards
1
Q
How do you determine if the drug is right for the bug?
A
Three main factors:
- Likely or known causative organism
- Empirical therapy (treatment started based on educational guess)
- Culture & sensitivities (known)
- Patient factors
- Topic 2
- Drug factors
- Topic 2
2
Q
What is empirical theory?
A
- This is the most common
- Here we are managing what we think is the most likely causative organism
- We are guided by local resistance patterns
3
Q
Following on for empirical theory:
A women presents the the GP with symptoms of UTI. She is young with no complications or pregnacny. What bacteria is the likely cause?
A
E.coli (Gram negative anaerobic)
Trimethoprim - Ecoli is mainly susceptible to this
4
Q
What is culture and senesitivity and why is it useful?
A
- When choosing an antibacterial, ideally want to use as narrow a spectrum as possible to minimise the risk of resistance developing
- One way to ensure that you are treating a known organism and treating it with the narrowest spectrum agent possible is to take culture & sensitivities
- May see it abbreviated in medical notes to C&S
- Culture is taken from the site of infection e.g. urine, sputum, blood etc, ideally BEFORE Abx treatment is commenced
- Sensitivities are then determined for a range of antibacterial agents
- Prescriber would choose (or alter therapy) based on the results – know as “streamlining” – usually involves moving on to a narrow spectrum when compared to the empiric therapy.
