COVID - Block 3 Flashcards
What is the primary method of transmission of SARs?
Direct person-to-person respiratory trasmission of infected particles
What is the most common clinical presentation of COVID?
Asymptomatic
Flu-like
Loss in taste and smell
SOB
No sneezing
Describe the progression of sx?
- Exposure
- Initial sx within 4-5 days up to 14
- Sx can persist for weeks to months
What are the phases of COVID?
- Early infection
- Pulmonary phase
- Hyperinflammation
RF of COVID?
- ≥65YO
- Smoker
- Medical comorbiiites/conditions
What is the most common diagnostic tool for COVID?
- NAAT -> RT-PCR
- Chest radiograph
Do asymptomatic infection test positive?
Yes
When are false negative most common?
Early infection
Chest radiograph findings in patients with COVID?
Ground glass opacties
What is the goal for outpatient tx?
- Prevent progession
- Hasten sx resolution
What is the goal of inpatient tx?
- Survival
- To prevent med vent
- Shorten hospital stay
Tx for mild-moderate outpatient?
Symptom management with:
First line: Nirmatrelvir/ritonavir (Paxlovid)
Remdesivir
Second: Molnupiravir
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Paxlovid
MOA, 0DDI, Duration of tx, ADR, Dosing adj0
Nirmatrelvir/ritonavir: PIs
DDI: Ritonavir is a CYP3A4 inhibitor
Duration: 5 days
ADR: taste disorder, diarrhea, COVID19-rebound (within 2-8 days after initial recovery)
Adj: GFR≤60
Remdesivir
MOA, Indication, Duration of tx
MOA: delayed chain terminator
Indication: Used within 7 days of sx onset
Duration: 3 days IV
ADR of remdesivir?
- Elevated LFTs
- Infusion rx
- Bradycardia
- Hypotension
- GI sx
- AKI
- Rash