Cough Flashcards
Causes of acute dry cough (4)
Asthma
Drugs (ACE inhibitors)
Heart failure
URTI (laryngitis, pharyngitis)
Causes of acute productive cough (2)
Pneumonia (LRTI)
TB
Causes of chronic dry cough (4)
Asthma
Lung cancer
GORD
Mesothelioma
Causes of chronic productive cough (4)
COPD
Bronchiectasis
Lung cancer
Cystic fibrosis
RF for pneumonia (3)
Smoking
Travel
Immunocompromised
Causes of atypical pneumonia (4)
Mycoplasma pneumonia
Legionella pneumophila
Chlamydia psittaci
Chlamydia pneumoniae
Causes of CAP pneumonia (3)
Strep pneumoniae (AKA pneumococcus)
Haemophilus influenzae B
Moraxella catarrhalis
Causes of HAP pneumonia (3)
Staph aureus
Pseudomonas aeruginosa
Which organism causes a transverse myelitis pneumonia
Mycoplasma pneumoniae
Which organism causes a hyponatraemic pneumonia
Legionella pneumophila
Which organisms causes a cavitating lesions pneumonia (2)
Staph aureus
Klebsiella
Which organism causes air conditioning associated pneumonia
Legionella pneumophila
Which organism causes pet birds associated pneumonia
Chlamydia psittaci
What pneumonia is Chlamydia psittac associated with
Pet birds
What pneumonia is Staph aureus associated with
Cavitating lesions
What is pneumonia Klebsiella associated with
Cavitating lesions
What is pneumonia legionella pneumophilia associated with (2)
A/C
Hyponatraemia
What is pneumonia mycoplasma pneumonia associated with
Transverse myelitis causing pneumonia
What extra symptoms do atypical pneumonias cause (5)
Dry cough Headache Diarrhoea Myalgia Hepatitis
What are the symptoms of typical pneumonia (5)
Fever SOB (dyspnoea) Cough (with green sputum) Chest pain (pleuritic) Confusion
What is auscultated in pneumonia (3)
Coarse bibasal crackles
Bronchial breathing
Increased vocal resonance
Ix for pneumonia (8)
Bloods FBC CRP ABG Blood cultures
Sputum MCS
Pleural fluid MCS (via thoracentesis)
CXR
Which extra Ix should you do if you suspect atypical pneumonia and which Ix suggests which pathogen (4)
Serology (all)
Urinary antigens (legionella, strep pneumo)
Blood film (mycoplasma – cold agglutins)
LFTs (legionella)
What is used to score pneumonia
CURB-65
Acute Mx of pneumonia (4)
Oxygen (+ sit up patient)
IV fluids
CPAP (if required)
Surgical drainage (if abscess/empyema)
Mx of CAP pneumonia
Amoxicillin (co-amoxiclav if severe)
Mx of HAP pneumonia (2)
If staph: Flucloxacillin + gentamycin
If MRSA: Vancomycin
Mx of atypical pneumonia (2)
Clarithromycin
Mx of aspiration pneumonia (2)
Metronidazole
Which type of pneumonia is metronidazole used for
Aspiration
Which type of pneumonia is clarithromycin used for
Atypical
Which type of pneumonia is amoxicillin used for
CAP
Which type of pneumonia is co-amoxiclav used for
Severe CAP
Which type of pneumonia is flucloxacillin used for
Staph with gentamycin
Which type of pneumonia is gentamicin used for
Staph with flucloxacillin
Which type of pneumonia is vancomycin used for
MRSA
What do you generally give pneumonia (2)
amoxicillin + clarithromycin
Complications of pneumonia (5)
Pleural effusion Pneumothorax Lung abscess (often Staph aureus) Empyema Sepsis
Which complications of pneumonia do staph commonly do (4)
Lung abscess (often Staph aureus)
Swinging fevers
Persistent pneumonia
Foul-smelling sputum
Which parts of the body can TB affect (8)
Lungs Brain Heart Spine Skin Testes GI Kidneys
What are the effects of TB on the skin (2)
Erythema Nodosum
Clubbing
What are the effects of TB on the brain
Meningitis
What are the effects of TB in the lungs (2)
TB pneumonia
Pleural effusion
What are the effects of TB on the GI system (2)
Peritonitis
Ascites
What are the effects of TB on the heart (3)
Pericardial effusion
Constrictive pericarditis
Normocytic anaemia
What are the effects of TB on the spine (3)
Pott’s disease
Spinal cord compression
Osteomyelitis
What are the effects of TB on the spine (2)
Epididymo-orchitis
Infertility
What are the effects of TB on the kidney (2)
Renal failure
Addison’s disease
Ix for TB not bloods (4)
Sputum MCS (x3 samples)
(microscopy with Ziehl-Neelsen stain
= enables visualisation of acid-fast bacilli)
CXR
Lymph node biopsy (caseating granuloma)
Mantoux/tuberculin skin test (TST)
IGRA
What stain is used to detent TB in sputum
Ziehl-Neelsen stain
What bloods do we take to detect TB and what are the results (2)
FBC
High WCC
CRP
High
What is seen in the CXR of TB (5)
Consolidation (patchy/heterogenous) Bi-hilar lymphadenopathy Upper lobe scarring (Cavitating lesions) (Pleural effusions)
What is seen in the CXR of miliary TB
Nodular shadowing
Define bronchiectasis
chronic condition that causes permanent dilation of the airways, alongside increased mucus production
Congenital causes of bronchiectasis (3)
CF
Primary ciliary dyskinesia (AKA Kartageners syndrome)
Youngs syndrome
What is the triad in primary ciliary dyskinesia (Kartagener’s syndrome)
Triad:
PCD
Sinusitis
Situs inversus
What is the triad in Youngs syndrome
Bronchiectasis
Sinusitis
Infertility
Acquired causes of bronchiectasis (6)
Pneumonia TB Measles Pertussis Allergic bronchopulmonary aspergillosis (ABPA) Immunocompromised (e.g. HIV)
Symptoms of bronchiectasis (6)
Chronic cough (+green sputum) Haemoptysis SOB Chest pain Fever Weight loss
Signs of bronchiectasis (2)
Clubbing
Bibasal crackles
Ix for bronchiectasis (not bloods, 4)
Sweat test
(Cystic fibrosis)
Sputum MCS
CXR
HR-CT chest (best method
How do you test for CF
Sweat test
What is the classic sign seen on CT of bronchiectasis
Classic feature
Signet ring sign
Conservative Mx of bronchiectasis (4)
Exercise
Good diet
Good hydration
Airway clearance
How can you practise airway clearance for bronchiectasis (3)
Chest physiotherapy
High frequency oscillation devices
Nebulised hypertonic saline
Medical Mx of bronchiectasis (4 and 1 more acute)
Inhaled salbutamol
Inhaled ABx (prophylactic)
(Oral azithromycin)
Influenza flu vaccine
IV ABx (acute) (IV levofloxacin – if pseudomonas)
Complications of bronchiectasis (3)
Persistent infections
Cor pulmonale (RHF)
Respiratory failure
Surgical Mx of bronchiectasis
Localised resection
What type of cell is small cell lung cancer
Endocrine cells
What type of cell is adenocarcinoma lung cancer
Goblet cells
What type of cell is squamous cell carcinoma
Squamous epithelial cells
What type of cell is large cell carcinoma
Epithelial cells
Associations of small cell lung cancer (2)
SIADH, ectopic ACTH
Associations of adenocarcinoma
Peripheral lung
Associations of SqCC
PTHrp
Which lung cancer is associated with PTHrp
SqCC
Which lung cancer is associated with SIADH
Small cell lung cancer
Which lung cancer is associated with ectopic ACTH
Small cell lung cancer
RF of lung cancer (3)
Age
Smoking
Asbestos exposure (particularly SqCC)
Which lung cancer is the most associated with asbestos exposure
SqCC
Symptoms of a primary lung cancer (6)
Cough (dry or productive) Haemoptysis SOB Weight loss Loss of appetite Night sweats
Symptoms of a local invasion of a lung cancer (2)
Nervous system (Horner’s syndrome) (left recurrent laryngeal nerve = bovine cough) Superior vena cava (SVC obstruction)
Where do lung cancers usually metastasise (4)
Bone (bone pain, fractures)
Brain (headaches, blurry vision)
Liver (hepatomegaly)
Lymphadenopathy
What is heard on auscultation of a lung cancer (4)
Wheezing
Increased vocal resonance
(Pleural effusion =decreased vocal resonance)
Crackles
Lung cancer blood tests and results (4)
FBC
Calcium
ALP
LFT
Lung cancer blood tests results:
Ca
ALP
LFT
High (bone mets)(PTHrp) May be high (bone metastases) Deranged (liver metastases)
What is seen in primary lung cancer CXR (5)
Consolidation (usually heterogenous) (Bi-hilar lymphadenopathy) (Upper lobe scarring) (Cavitating lesions – usually SqCC) (Pleural effusions)
What is seen in primary lung cancer CXR (5)
Consolidation (usually heterogenous) (Bi-hilar lymphadenopathy) (Upper lobe scarring) (Cavitating lesions – usually SqCC) (Pleural effusions)
Define mesothelioma
malignant neoplasm of mesothelial cells of the pleura (rare condition)
RF of mesothelioma
Asbestos exposure
Symptoms of mesothelioma (5)
Cough (dry) SOB Weight loss Loss of appetite Night sweats
What is heard on auscultation of mesothelioma that is a dead give away
Pleural friction rub
Which bloods do you take for mesothelioma (4)
FBC
Calcium
ALP
LFT
Mesothelioma results:
Calcium
ALP
LFT
High PTHrp
ALP may be high
LFT may be deranged if liver mets
Main Ix for mesothelioma (2)
CXR
CT chest
Ix for mesothelioma (4)
CXR
CT chest
Pleural fluid (cytology)(via thoracentesis) Pleural biopsy