Cortisol And Thyroid Disorders Flashcards

1
Q

What is the disease name for Hypercortisolism?

A

Cushing’s disease

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2
Q

What is the name of the disease for Hypocortisolism?

A

Addison’s disease

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3
Q

Individuals with hypercortisolism will manifest with a rise in plasma ___________ levels.

A

Glucose

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4
Q

Why do individuals with Cushing disease or syndrome develop a thinning of the dermis that leads to skin ulcerations?

A

Elevated cortisol promotes the breakdown of collagen in the dermis.

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5
Q

The most common cause of hypocortisolism is:

A

autoimmune destruction of adrenal cortex .

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6
Q

What are life threatening manifestations of severe hypocortisolism?

A

Hypoglycemia

Hypotension

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7
Q

A patient is diagnosed with secondary hyperthyroidism manifested by elevated T3/T4 and elevated TSH. What is a possible cause of this condition?

A

Pituitary gland adenoma

A pituitary gland tumor can over secrete TSH which leads to secondary hyperthyroidism.

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8
Q

What correctly describes the pathophysiology of Graves disease?

A

Production of antibodies that mimic TSH function

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9
Q

Which metabolic change is indicative of hyperthyroidism?

A

Weight loss

Increased T3/T4 levels causes a corresponding increase in the body’s metabolic rate, which leads to symptoms such as weight loss.

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10
Q

Which clinical consequences are associated with long term, untreated hypothyroidism?

A

weight gain.
diminished reflexes.
myxedema.

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11
Q

Which problem is a consequence of Hashimoto’s disease?

A

Hypothyroidism

Hashimoto’s disease or thyroiditis is caused by the production of antibodies that block TSH activity. This results in hypothyroidism.

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12
Q

A 46-year old woman is hospitalized following surgery to remove her thyroid gland (i.e., a thyroidectomy) due to thyroid cancer. Which assessment finding would the nurse be monitoring for immediately following the surgery?

A

Hypotension

A thyroidectomy is a surgery that results in the removal of the thyroid gland. Without a thyroid, the body cannot produce thyroid hormone (T3/T4). This puts the post-operative patient in a state of hypothyroidism until supplemental thyroid hormone (e.g. levothyroxine) can be started. Normally, thyroid hormone stimulates the sympathetic nervous system to raise blood pressure. Without thyroid hormone, the patient can become become dangerously hypotensive.

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13
Q

A patient is admitted to a medical surgical unit with a diagnosis of Addisonian crisis (i.e., severe Addison’s disease). Which findings should the interprofessional healthcare team focus on?

A

Hypoglycemia

Hypotension

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14
Q

The nurse is preparing a client with a new diagnosis of Graves disease for discharge. the nurse determines that the client understands the discharge instructions if the client states that which signs and symptoms are associated with this diagnosis?

A

Insomnia

Rapid heart rate and palpitations

Tremors

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15
Q

What are the clinical consequences of Hypercortisolism?

A

Hyperglycemia
Collagen breakdown in skin and blood vessels
Hypertension
Immunosuppression

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16
Q

What are the physical body changes that Hypercortisolism causes?

A

weight gain; round face/fat pad development on upper back, central obesity, thin extremities.

17
Q

What is the primary hypocortisolism?

A

Atrophy or destruction of adrenal cortex leads to decreased cortisol and aldosterone secretion

18
Q

What causes hypocortisolism?

A

Autoimmune destruction of adrenal cortex
Genetic conditions (e.g., familial adrenal insufficiency
Tuberculosis

19
Q

What causes Secondary Hypocortisolism?

A

Injury to the anterior pituitary leading to decreased ACTH secretion (e.g., tumor, stroke…)

20
Q

What are the clinical consequences of hypocortisolism?

A

Hypoglycemia
Fatigue
Hypotension

21
Q

Which condition is a clinical consequence of hypercortisolism (Cushing disease or syndrome)?

A

Increased risk for infection

22
Q

Which condition a clinical manifestation of hypocortisolism (i.e., Addison disease)?

A

Hypoglycemia (low blood sugar)

23
Q

What is Secondary hyperthyroidism?

A

Excessive production of thyroid stimulating hormone (TSH) from the anterior pituitary gland leads to excess T3/T4 production.

24
Q

What causes Primary Hyperthyroidism?

A

Thyroiditis (viral or autoimmune injury)
Toxic nodular or multinodular goiter (Plummer disease)
Thyroid adenoma (benign tumor)
Thyroid cancer

25
Q

What causes Secondary Hyperthyroidism?

A

TSH-secreting pituitary benign or cancerous tumors
Graves Disease
Overdose of thyroid replacement medication (thyrotoxicosis)

26
Q

What are the clinical consequences of Hyperthyroidism?

A

Increased metabolic rate
• Increased body temperature
• Weight loss
Increased neuromuscular activity
• Hyperactive reflexes
• Tremors, anxiousness, insomnia
Increased SNS stimulation
• Tachycardia (increased heart rate)
• Hypertension (increased blood pressure)

27
Q

What is Graves’ disease?

A

An autoimmune disease causing hyperthyroidism

28
Q

What does grave disease causes?

A

Overproduction of thyroid autoantibodies called thyroid stimulating
immunoglobulin (TSI)
TSIs mimic effect of thyroid stimulating hormone (TSH)
Elevated levels of TSI’s stimulate excess T3/T4 secretion

29
Q

What are the clinical consequences of Graves disease?

A

Exopthalamus
Degeneration of extraocular muscles and edematous fluid accumulation in orbit leads to protruding eye ball
Possible optic nerve and retina damage

30
Q

What is Primary hypothyroidism?

A

Loss of thyroid tissue leads to decreased T3/T4

31
Q

What is Secondary hypothyroidism?

A

Failure of pituitary to synthesize adequate TSH.

32
Q

What causes Primary Hypothyroidism?

A

Iodine deficiency (enlarged thyroid gland (goiter))
Congenital lack of thyroid tissue
Surgical removal of the thyroid (thyroidectomy)
Hashimoto’s thyroiditis

33
Q

What causes Secondary Hypothyroidism?

A

Stroke to hypothalamus or pituitary
Pituitary tumor (benign or cancerous)
Postpartum pituitary necrosis

34
Q

What are the clinical consequences of decreased T3/T4?

A

Decreased metabolic rate
• Decreased body temperature
• Weight gain
Decreased neuromuscular activity
• Hypoactive reflexes
• Fatigue
• Confusion, decreased level of consciousness (with severe hypothyroidism)
• Balance problems and increased risk for falls
Decreased SNS stimulation
• Bradycardia (decreased heart rate)
• Hypotension (decreased blood pressure)