corticosteroids Flashcards
1
Q
corticosteroids group
A
glucocorticoids
2
Q
corticosteroids moa
A
- inhibits phospholipase A2
- vasoconstriction
- antiproliferative
- anti inflammatory
- immunosuppressive action
3
Q
corticosteroids uses
A
- replacement therapy- acute adrenal insufficiency, addison’s disease
- rheumatoid arthritis, osteoarthritis, rheumatic fever
- SLE,PAN, nephrotic syndrome, Glomerulonephritis
- severe allergic reaction
- autoimmune disease such as hemolytic anemia, ITP
- bronchial asthma
- ulcerative colitis, crohn’s disease, celiac disease
- malignancy such as leukemia, Hodgkin’s lymphoma
4
Q
corticosteroids A/E
A
- cushing’s habitus- round face, narrow mouth, hump, obesity
- fragile skin, purple striae, bruising, hirsutism
- hyperglycemia
- myopathy
- susceptibility to infection
- delayed healing of wounds
- osteoporosis
- growth retardation
- fetal abnormalities
5
Q
corticosteroids classification
A
- hydrocortisone(short acting t1/2<12 hrs)
- prednisolone (intermediate t1/2 12-36 hrs)
- dexamethasone (long acting t1/2 >36hrs)
