chloramphenicol

Question 1

chloramphenicol group

Answer 1

• nitrobenzene derivative

Question 2

chloramphenicol moa

Answer 2

• interferes with protein synthesis(50s ribosome)

- primarily bacteriostatic but at higher dose bactericidal

Question 3

chloramphenicol uses

Answer 3

• pyogenic meningitis
• anaerobic infection caused by bacterial fragilis(wound infection, intraabdominal infection, pelvic abscess, brain abscess)
• intraocular infection(endophthalmitis)
  second line of drug to tetracycline in treatment of brucellosis, rickettsial infection

Question 4

chloramphenicol A/E

Answer 4

• bone marrow depression (aplastic anemia, agranulocytosis, thrombocytopenia, pancytopenia)
• hypersensitivity reaction- rashes, fever and atrophic glossitis
• n/v, diarrhea, pain at injection site
• superinfection
• gray baby syndrome