CORE Breast Flashcards
when to use US
when a felt lump not seen on mammogram
MRi indications include
high risk patients
evaluation of diangosed diseased
chemo response
residual disease
recurrene
occult breast cancer with axillary mets
assessment of breast implants
what is the pathogenesis pathway of breast cancer
Normal
Flat epithelial atypia
atypical ductal hyperplasia
DCIS
IDC
what is upstaging
cancer i supstaged after excision
an increase from the core biospy
what does BRCA1 / BRCA2 mutation cause
increase lifetime risk of breast cancer
80% by 80
other risk factors for breast cancner
age, female
1st degree relative
prior chest radiatin
long term estrogen exposure
most common subtype of breast cancer is
IDC
IDC apperance
felt lump
irregular mass spiculated margins and ax pleomorphic clacifications
what are the other types of breast cancer
Tubular
Mucinous
Medullary
encapsulated papillary / solid papillary
adenoid cystic carcinoma
mucinous carcinom more common
in old women
Medullary carcinoma is found in
younger women with BRCA1 gene mutation
Appearanc3e of an encapuslated papillary carcinoma
discharge.
round oval mass.
circumscrbied margins.
US complex cystic solid mass.
inflammatroy carcinoma will appear as
skin distortion
edema
mammo - large, dense, trabecular thickening.
what is pagets disease of the nipple
DCIS that infiltrates the nipple epidermis
erythema of the nipple
non metastatic disease most important prognostic factor
axillary lymph nodes
when to do lymph node dissection vs sentinal biopsy
dissection is done if sentinel lymph node is positive
or not identified
is Er and Pr a good thing
Yes
longer survival
if have HER2 what can you give
trastuzamab - herceptin
Tk inhibitor like lapatinib
triple negative is
bad
common with BRCA1 mutation
What does BIRADS 0 mean
more imaging required
only used in screening
BIRADS 1
normal
BIRADS 2
definitely benign
vacsular, bening calc
simple breast csts, inflammatory lymph nodes