COPD and Asthma drugs

Question 1

Titotroprium

Answer 1

long-acting, antimuscarinic bronchodilator (LAMA)

inhibits M3 muscarinic receptors in lung SM ⇒ relaxation of SM + bronchodilation

Question 2

MoA of B2-agonists

Answer 2

• inhibit B2-R in bronchial SM -> relaxation:
• decrease mast cell degranulation + histamine release
• increase mucociliary clearance

Question 3

Type of Bronchodilators that take effect within mins + active for up to 6-8hrs and their use

Answer 3

Short-acting

• relief of acute bronchoconstriction + prevention of exercise-induced asthma

Question 4

Indacaterol

Answer 4

Ultra-long acting Beta2 agonist

Question 5

Give 2 examples of long-acting beta-2 agonists

Answer 5

Salmeterol + Formeterol

Question 6

Give 2 examples of short-acting beta-2 agonists

Answer 6

Salbutamol, Albuterol