Block 12+13 Drugs Flashcards
MoA of ACE inhibitors and their effects
- bind and inhibt ACE action in lungs
- prevents conversion of AT I –> AT II
- so decreased AT II production:
> Arterial and venous vasodilation
> Decreased systemic vascular resistance
> decreased bradykinin production
> Sustained decreases in LV filling pressure during rest and exercise
Most common side effect of ACE inhibitors
dry, irritating cough
MoA of Calcium channel blockers
- inhibit calcium influx during membrane depolarisation
> reduces LV contractility –> +ve inotropic effect
> vasodilation
> reduces myocardial oxygen demand
> slow HR
> decrease total peripheral resistance → reduce BP
Give examples of dihydropyridine calcium channel blockers
Amolodipine
Nifedipine
Give examples of Non-dihydropyridines Ca2+ channel blockers
Verapamil
Diltiazem
Potent peripheral vasodilators that have a positive inotropic effect
Calcium channel blockers
Side effects of Calcium channel blockers
- GORD
- light headedness
- low BP
- slow HR
- drowsiness
- flushing
- ankle oedema
- increased appetite
Non-selective Beta Blockers
- bind beta 1 and beta 2 adrenoreceptors
Propanolol, Timolol, Nadolol
Cardioselective beta blockers
Bisoprolol
Atenolol
Side effects of Warfarin
- teratogenic
- purple toes
- skin necrosis
- haemorrhage
Epilepsy drugs
Highly protein bound, narrow therapeutic index + inhibits Na+ channels
Phenytoin
Epilepsy drugs
Action of lamotrigine
inhibits aspartate + glutamate release by directly inhibiting neurons tht synthesise them
Drug that is usually restricted to absence seizures AND inhibits T-type Ca2+ channels
Ethosuximide
