Antivirals Flashcards

1
Q

Aciclovir

A

DNA polymerase inhibitor

- incorporated into viral DNA -> acts as termination signal

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2
Q

Amantadine

A
  • inhibits viral protein M2 - ion channel needed for viral particle to become β€œuncoated” once it is taken inside the cell by endocytosis

also used as antiparkinson agent

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3
Q

Amprenavir

A

protease inhibitor

  • inhibits HIV-1 protease
  • leads to formation of immature non-infectious viral particles

suffix: -navir

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4
Q

Zidovudine

A

nucleoside reverse transcriptase inhibitor

thymidine analogue

prevents chain elongation β‡’ chain termination

suffix: -vudine

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5
Q

Long-term use of protease inhibitors can cause

A

lipodystrophy (wasting of peripheral fat, accumulation of central fat, hyperlipidemia, and insulin resistance

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6
Q

Zanamivir

A

Neuraminidase inhibitors

- prevents virus leaving host cell + infecting other cells

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7
Q

Remedesivir

A

inhibits RNA dependent RNA polymerase

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8
Q

Vidarabine

A

adenosine analogue
inhibits viral DNA polymerase
acts as chain terminator

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9
Q

Foscarnet

A

mimics pyrophosphate + inactivates DNA polymerase

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10
Q

Hydroxycarbamide

A

inactivates ribonucleotide reductase reduces production of deoxyribonucleotides β‡’ inhibits DNA synthesis

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11
Q

Maraviroc

A

CCR5 antagonist blocks gp120 from interacting w CCR5 on CD4+ cell

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12
Q

Enfuvirtide

A

blocks gp41 from fusing w cell membranes

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13
Q

Bicetagravir

A

blocks viral integrase prevents incorporation of proviral HIV DNA into host cell genome

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