Control Of The Cell Cycle Flashcards
1
Q
What does a uncontrolled reduction in the cell cycle may result in
A
Degenerative disease
2
Q
What does a uncontrolled increase of cell result in
A
Formation of a tumour
3
Q
What is checked at the G1 checkpoint
A
Size and mass of cell- growth
4
Q
What is monitored during the G2 checkpoint
A
DNA replication success 
5
Q
What is monitored during the M phase checkpoint? 
A
Chromosome alignment on the metaphasic plate 
6
Q
What does active CDK cause of target proteins that stimulate the cell cycle? 
A
Phosphorylation
7
Q
What is the retinoblastoma protein?
A
Transcription factor inhibitor 
8
Q
What does the binding of the Rb to the transcription factor inhibit and what does this cause? 
A
Inhibits the transcription of the genes required to that enter the S phase
