Control of gene expression in eukaryotes part 5

Question 1

Define leaky scanning

Answer 1

Absence of Kozak sequence, so start codon isnt always the same for the gene. Results in two different forms of the gene being made.

Question 2

Define SRIC

Answer 2

A protein complex that scans the 5’ region for an appropriate start sequence

Question 3

What are uORFs?

Answer 3

upstream reading frames: located in the 5’UTR, they attenuate the transcription of the actual reading frame further downstream

Question 4

What are IRES?

Answer 4

Internal Ribosome Entry Sites

Question 5

What is the mechanism of IRES?

Answer 5

Produces a hairpin that can recruit specialized proteins typically associated with Cap-dependent translation