constipation and diarrhea Flashcards
signs and symptoms of constipation
anorexia, dull headache, low back pain, abdominal discomfort, bloating, and flatulence
primary cause of constipation
inadequate dietary fiber, fluid intake, and/or exercise
structural conditions causing constipation
anal fissure and pregnancy
systemic conditions that cause constipation
- endocrine: thyroid disorders, diabetes
- IBS
- MS, neuropathy
- parkinsonism
- dementia
psychological conditions that cause constipation
depression, eating disorders, stress, changes in routine
medications that can cause constipation
anticholinergics, TCA, benzodiazepines, cholestyramine, calcium, and iron supplements
exclusions for constipation
- significant abdominal pain or cramping or distention
- unexplained flatulence
- fever or NV
- unexplained changes in bowel habits
- marked change in the character of stool
- rectal bleeding
- < 2 years of age
- anorexia
- inflammatory bowel disease, colostomy
- 14 days of symptoms or recurrences over 3 months
- 7 days of OTC treatment
non pharm therapy
gradually increase high-fiber food, increase fluid intake, exercise regularly
increase these foods for a high-fiber diet
fruits, vegetables, whole grains
decrease these foods for a high-fiber diet
meat, chest, processed foods
fiber intake for women
25 grams
fiber intake for males
38 grams
examples of bulk forming agents (fiber supplements)
methylcellulose, polycarbophil, and psyllium
onset of fiber supplements
12-72 hours
ADE of fiber supplements
abdominal discomfort and flatulence
fiber supplement precautions
swallowing difficulties, GI ulcer, high calcium content in polycarbophil, sugar content in some formulations
first choice for pregnant women
fiber supplements
MOA fiber supplements
dissolves and swells in intestines and adds bulk and water to stool
examples of emollient agents (stool softeners)
docusate
MOA of stool softeners
- surfactant
- facilitates mixture of aqueous and fatty substances to soften stool
- lower surface tension of stool, allowing more water to enter stool
onset of stool softeners
12-72 hours
ade for stool softeners
minimal
precautions of stool softeners
larger than recommended doses can lead to sweating, muscle cramps, and irregular heartbeat.
contraindications with stool softeners
mineral oil`
examples of hyperosmotic agents
PEG 3350 and glycerin
MOA of hyperosmotic agents
contain large, poorly absorbed ions or molecules that draw water into the colon or rectum through osmosis
peg3350 onset
12-72 hours
glycerin onset
15-30 min
ade of peg3350
bloating, abdominal discomfort, cramping, flatulence
glycerin ade
rectal irritation
peg3350 precaution
fda approved labeling indicates patients with renal disease or OBS should consult PCP prior to use
glycerin precaution
avoid if preexisting rectal irritation
peg3350 age requirements
must be at least 17 yoa
examples of stimulants
senna and bisacodyl
MOA of stimulants
increase motility by stimulation of intestinal SM (causing intestines to contract and push out stool), increase secretion of water and electrolytes in the intestines
onset of po stimulants
6-10 hours
Bisacodyl suppository onset
15-60 min
ade of stimulants
cramping and local irritation of the mucosa
stimulant precautions
electrolyte or fluid deficiencies, malabsorption due to hypermotility
DDI with stimulants
avoid with antacids
opioid induced constipation
docusate and stimulant combo typically
examples of lubricant agents
mineral oil
moa of mineral oil
coats stool and prevents absorption of water into the colon
po onset of mineral oil
6-8 hours
rectal onset of mineral oil
5-15 min
when using mineral oil avoid..
- < 6 years of age
- pregnancy
- bedridden/elderly
- difficulty swallowing
- aspiration risk
contraindication of mineral oil
docusate
eating and mineral oil
impairment of absorption of fat-soluble vitamins (do not take within 2 hours of eating)
mineral oil use
avoid if possible, better and safer treatment alternatives are available
examples of saline laxative agents
magnesium citrate, magnesium hydroxide, magnesium sulfate, sodium phosphates
MOA of saline laxatives
ions draw water into the intestines by osmosis, increasing intraluminal pressure and promoting GI motility
po onset of saline laxatives
30 min - 6 hours
rectal onset of saline laxatives
up to 15 min
ade of saline laxatives
abdominal cramping, NV, dehydration, hypermagnesemia
precautions for saline laxatives
elderly, electrolyte changes, renal failure, restricted diet (na, phos, mg), CHF, use with diuretics
saline laxative use
used prior to colonoscopy to evacuate bowel and take with water to prevent dehydration
acute diarrhea
symptoms lasting less than 14 days
persistent diarrhea
symptoms lasting 14 days to 4 weeks
chronic diarrhea
symptoms lasting > 4 weeks
minimal to no dehydration
self treatable good, alert mental status drinks normally normal HR mouth is moist skin has instant recoil capillary refill is normal\ extremities are warm urine output is normal/decreased < 3 stools/day
mild-moderate dehydration
self treatable normal, fatigue mental status eager to drink normal or increased HR mouth is dry skin recoils < 2 seconds capillary refill is prolonged extremities are cool urine output is decreased 3-5 stools/day
severe dehydration
not self treatable apathetic or lethargic mental status unable to drink tachy or bradycardia mouth is parched skin recoils in > 2 seconds capillary refill is prolonged and minimal cold extremities urine output is minimal 6-9 stools/day
exclusions for diarrhea
- infants < 6 months of age
- moderate diarrhea < 2 yo
- children with high fluid output, fever, or mental status changes
- severe diarrhea
- stool containing blood/mucus
- DM, cardiac/renal disease, URTI
- severe abdominal pain, cramping, tenderness, distention
- pregnancy
- immunocompromised
nonpharm treatment
ORS, preventative measires
loperamide MOA
synthetic opioid agonist
produces antidiarrheal effects by slowing intestinal motility, lacks CNS effects bc it is a substrate for p-glycoprotein
loperamide indication
symptomatic relief of acute, nonspecific diarrhea
ade of loperamide
dizziness and constipation
precautions for loperamide
should not be used in invasive bacterial diarrhea, children < 6 or in patients taking saquinavir
length of use for loperamide
no more than 2 days
loperamide warnings
serious heart problems with misuse and abuse
BSS MOA
reacts with hydrochloric acid in the stomach to form bismuth oxychloride and salicylic acid, exerts antibacterial effects and antisecretory effects
BSS indication
acute diarrhea, travelers diarrhea prophylaxis, or indigestion
ade of BSS
tinnitus (dose related), gout, reyes syndrome, black staining of stool and darkening of tongue
precautions of BSS
children < 12
patients with lactate deficiency
lactase enzymes
probiotics
lactobacillus, Bifidobacterium lactis, saccharomyces boulardii
zinc supplementation
reduces duration, severity, and persistence of acute diarrhea in children < 5