Allergic Rhinitis Flashcards

1
Q

When does allergic rhinitis develop?

A

usually after 2nd year of life; it is prevalent in children and adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

types of allergic rhinitis

A
  • seasonal (hay fever)
  • perennial
  • intermittent (sxs 4 days a week or less OR lasts 4 weeks or less)
  • persistent (sxs more than 4 days a week or more OR lasts greater than 4 weeks)
  • mild (sxs do not interfere with daily activities)
  • moderate-severe (impairment of sleep, daily activities, or bad symptoms)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

risk factors of allergic rhinitis

A

family hx of allergic disorders (atopy), filaggrin gene mutation, elevated serum IgE under 6 years of age, higher socioeconomic class, eczema, positive reaction to allergy skin tests, children eating three or more fast food meals per week

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

allergic rhinitis mediated response

A

IgE; involves release of mast cell mediators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

4 phases

A

sensitization, early phase, cellular recruitment, late phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

AR symptoms and findings

A

bilateral symptoms, worse when awakening and at night, frequent or paroxysmal sneezing, anterior watery rhinorrhea, pruritis of eyes/nose, conjunctivitis, allergic shiners, wrinkles below lower eyelids, allergic crease, allergic salute, allergic gape

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

AR causes and triggers

A

pollen, mold. pollutants, dust mites, cockroaches, smoke, pet dander, wool dust, latex, resins, biologic enzymes, organic dusts, chemicals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

non-AR symptoms and findings

A

unilateral symptoms, constant day and night, little or no sneezing, posterior watery or thick rhinorrhea, nasal obstruction, anosmia, epistaxis, nasal polyps, enlarged tonsils, nasal septal deviation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

non-AR causes and triggers

A

puberty, pregnancy, thyroid, septal deviation, cocaine, BB, ACEI, chlorpromazine, clonidine, NSAIDS, aspirin, overuse of topical decongestants, systemic inflammatory, lesions/polyps, facial or head trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

symptoms of AR

A

itching nose, palate, sneezing, watery rhinorrhea, postnasal drip, nasal congestion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

complications of AR

A
  • acute: sinusitis, otitis media with effusion

- chronic: nasal polyps, seep apnea, sinusitis, hyposmia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

treatment approach

A
  1. allergen avoidance
  2. pharmacotherapy
  3. immunotherapy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

goals of treatment

A
  • reduce symptoms
  • improve functional status and sense of well-being
  • individualize to provide optimal symptomatic relief/control
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

exclusions to self-care

A
  1. undiagnosed
  2. children under 12 and pregnant/lactating women
  3. signs and symptoms of non-AR
  4. signs and symptoms of infection
  5. signs and symptoms of undiagnosed or uncontrolled asthma or other lower respiratory disorders
  6. unacceptable/severe treatment SE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

non-pharmacologic management

A
  • allergen avoidance
  • lower household humidity
  • limit exposure to pets
  • vacuum frequently (avoid carpeting and upholstered furniture)
  • HEPA filters
  • saline nasal spray
  • Neti pot
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

for initial treatment of seasonal AR in persons aged 12 years or older

A

routinely prescribe monotherapy with an intranasal corticosteroid rather than an intranasal corticosteroid in combination with an oral antihistamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

for initial treatment of seasonal AR in persons aged 15 years or older

A

recommend an intranasal corticosteroid over a leukotriene receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

for treatment of moderate to severe seasonal AR in persons aged 12 or older

A

the clinician may recommend the combo of an intranasal corticosteroid and an intranasal antihistamine for initial treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

triamcinolone

A

Nasacort allergy 24 hr and children’s Nasacort allergy

2 years and older

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

examples of intranasal glucocorticoids

A
  • triamcinolone
  • fluticasone propionate
  • budesonide
  • fluticasone furoate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

fluticasone propionate

A

Flonase allergy relief and children’s Flonase allergy relief
4 years and older

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

fluticasone furoate

A

Flonase sensimist allergy relief

2 years and older

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

budesonide

A

rhinocort allergy spray

6 years and older

24
Q

intranasal glucocorticoids are effective for nasal symptoms and congestion because

A

they inhibit multiple cell types and mediators and also effectively stops the allergic cascade

25
Q

are IG’s sedating?

A

no

26
Q

how often do you use IGs

A

once daily administration (shake well before use)

27
Q

FDA warnings on IG

A

increased risk of growth inhibition in children and should be limited to less than two months per year without the supervision of a health care provider

28
Q

moa of antihistamines

A

compete with histamine at central and peripheral histamine receptor sites and prevents the histamine-receptor interaction which prevents the subsequent mediator release

29
Q

first generation antihistamines usage for AR

A

controversial due to the risks of sedation and anticholinergic effects

30
Q

classes of first generation antihistamines

A

alkylamines and ethanolamines

31
Q

alkylamines

A

most potent antihistamines, moderately sedating, higher risk of paradoxical CNS stimulation than other classes

32
Q

examples of alkylamines

A

chlorpheniramine
brompheniramine
dexbrompheniramine

33
Q

ethanolamines

A

highly sedating, strong anticholinergic effects, large doses can cause seizures and arrhythmias

34
Q

examples of ethanolamines

A

diphenhydramine
doxylamine
clemastine

35
Q

second generations usage in AR

A

effective with little to no sedation; effective in reducing itching, sneezing and rhinorrhea but has little effect on nasal congestion

36
Q

classes of second generation antihistamines

A

piperidines and piperazines

37
Q

piperidines examples

A

fexofenadine, loratadine

non-sedating

38
Q

piperazines examples

A

cetirizine, levocetirizine, and meclizine

minimally to moderate sedating

39
Q

DOC in pregnancy

A

chlorpheniramine

loratadine, cetirizine and diphenhydramine are also acceptable

40
Q

DOC in breastfeeding

A

no antihistamines

41
Q

DOC in children

A

loratadine followed by fexofenadine and cetirizine (sedating AH avoided due to excitation and risk of AE with misuse

42
Q

DOC in elderly

A

loratadine, intranasal cromolyn

43
Q

Narrow angle glaucoma

A

sedating AH should be avoided

44
Q

when to discontinue AH before allergy skin test

A

at least 4 days

45
Q

what AH shouldn’t be taken with fruit juice

A

fexofenadine (separate with at least two hours)

46
Q

which AH’s are photosensitizing

A

all sedating AH

47
Q

what AH should be used cautiously in those requiring mental alertness

A

sedating AH and cetirizine/levocetirizine

48
Q

decongestants are appropriate for use in patients with

A

AR accompanied by congestion

49
Q

antihistamine + systemic decongestants

A
  • useful in patients with nasal congestion + allergies

- should only use short term unless MD says

50
Q

mast cell stabilizers

A

cromolyn sodium (treats and prevents)

51
Q

moa of CS

A

works on the surface of mast cells to inhibit degranulation

52
Q

onset of action for CS

A

3-7 days, full efficacy seen in 2-4 weeks

53
Q

counseling on when patients should start taking CS

A

approximately 4 weeks prior to expected allergy season

54
Q

is CS used for relief of acute symptoms?

A

no, efficacy is generally considered to be somewhat less than oral antihistamines

55
Q

CS administration

A

nasal spray; one spray each nostril 3-6 times daily at regular intervals

56
Q

CS approved in

A

patients older than 5 and preferred in pregnancy/lactation