Consolidation Flashcards
1
Q
Ribot’s Law
A
- law of regression
- temporally graded nature of memory lose
- closer to injury = greater loss
2
Q
Standard consolidation theory
A
-things occur that transform hippocampal representatinos into representations in other places so that they no longer depend on the hippocampus
3
Q
system consolidation
A
- process within the standard consolidation theory that transforms a memory trace into a durable representation outside of the MTL
- cortex learns more slowly than hippocampus, but it is also capable of storing conjunctive /associative memories
- replay (reinstatement) allow the cortex to learn the associations
- repeated co-activation leads to cortex binding and forming conjunctive memories
4
Q
system consolidation as an explanation for temporally graded retrograde amnesia
A
- recent events haven’t had a chance to be consolidated in cortex so MTL damage decreases the chance that the events will be remembered
- remembering depends on the hippocampus until links in the cortex have been consolidated
5
Q
Sleep-dependent hippocampal replay
A
- rodent ran around a circular track
- place neurons fire in response to where the animal is in space
- can see firing pattern as the mouse moves through space
- compare to activity when the rat is asleep
- similar activity when asleep as when awake
- sleep activity is compressed (Temporally) replay of waking pattern of activity
6
Q
Human studies of consolidation (odor)
A
- play concentration card game with odor present in room
- sleep in MRI
- present the odor (while asleep)
- more activity in hippocampus when present with odor from learning while the subject was sleeping
- better performance when odor was presented during sleep
7
Q
Human studies of consolidation (sound)
A
- showed object locations paired with a sound
- tested: shown object, need to indicate location
- nap, play sounds during sleep (corresponding to cued objects)
- test again
- more accurate for cued memory after nap compared to testing before sleep
