consciousness, unconsciousness and sleep Flashcards

1
Q

what is consciousness?

A

a state if self-awareness, perception, ability to respond to stimuli, ability to act with judgement

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2
Q

what is sleep?

A

state of changed consciousness from which a person can be aroused by stimulation, alternating in an 24 hour cycle (circadian rhythm) with wakefulness

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3
Q

what is a coma?

A

a state of profound unconsciousness characterised by inability to sense and respond to external stimuli and loss of sleep wake cycle

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4
Q

what are the causes of a coma?

A

-intoxification
-acute neurologic injuries
-metabolic disorders
-CNS infection
-stroke

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5
Q

what is the duration of a coma?

A

generally a few days to a few weeks (2-5 weeks)
-some patients progress to a vegetative state or die

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6
Q

what is vegetative state?

A

-a state of unconsciousness in patients with severe brain injury
-frequently observed in patients in whom coma has progressed to certain state of wakefulness without awareness

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7
Q

what is brain death?

A

-irreversible coma, characterised by a lack of brain activity
-loss of pain responses and cranial nerve reflexes

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8
Q

what are examples of different biological rhythms?

A

-circadian rhythm - sleep/ wakefulness , hormone secretion etc
-infradian rhythm eg menstrual cycle
-ultradian rhythms - REM cycles

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9
Q

describe circadian rhythm

A

-24 hour biological clock
-a timing signal eg sunrise can reset the clock

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10
Q

what is metatonin?

A

-hormone secreted by the pineal gland in the brain
-secreted at night to help with sleep

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11
Q

what are the sleep stages?

A
  1. slow wave sleep (NREM) - stages I,II,III,IV
  2. Rapid eye movement (REM)
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12
Q

how long are the sleep stages and how many times are they repeated per night?

A

-90 min cycles
-repeated 5-6 times per night

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13
Q

what are brain waves measured on?

A

Electroencephalogram (EEG)

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14
Q

how can an EEG be applied clinically?

A

-sleep
-seizures
-altered consciousness
-focal and diffuse disturbances in cerebral functioning

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15
Q

Describe sleep stage 1

A

-light sleep, lasts for a few minutes
-easily awakened
-slow eye movements
-muscle activity slows down
-theta waves have a high amplitude on EEG

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16
Q

describe sleep stage 2

A

-eye movements stop
-brain waves become slower, with an occasional burst of rapid waves called spindels

17
Q

Describe stage 3 of sleep (NREM)

A

-extremely slow brain waves called delta waves appear, interrupted by smaller, faster waves

18
Q

describe stage 4 sleep

A

-nearly exclusive production of delta waves
-difficult to wake a person up
-latest and deepest stage of sleep before REM

19
Q

what is the REM stage of sleep?

A

-the brain waves seen on an EEG during REM are similar to the waves seen when awake
-this stage of dreaming is associated with dreaming

20
Q

what happens with sleep duration as we age?

A

total duration of sleep decreases

21
Q

what are examples of benefits of sleep?

A

-improves cognitive ability
-solidifies memory
-processes & repackages newly learned lessons
-increases decision making skills

22
Q

what physiological effects can sleep deprivation have on the body?

A

-increased BP
-increased HR
-disrupts glucose metabolism
-increases obesity

23
Q

in what situations can the REM stage be reduced during sleep?

A

-during shortened sleep periods
-alcohol
-nicotine
medications eg anti-depressants

24
Q

what part of the brain controls the REM/NREM cycles of sleep?

A

the reticular formation

25
what part of the brain controls the sleep/wake cycle?
suprachiasmatic nucleus
26
what system in the brain determines the level of alertness ?
the reticular activating system
27
what 2 types of neurons are important in the reticular activating system?
-neurons that synthesise ACH -neurons which synthesise monoamines eg noradrenaline, serotonin and histamine
28
describe the changes in activity in arousal pathways (ie 2 types of neurons) - during sleep stages
-during NREM / slow wave sleep - cholinergic and monoaminergic pathways slow down -during REM sleep, cholinergic neurons fire rapidly & monoaminergic neurons stop firing
29
what does the suprachiasmatic nucleus in the hypothalamus receive inputs from in order to control the sleep/wake cycle?
the retina
30
what are examples of sleep disorders?
-insomnia -excessive daytime sleepiness -obstructive sleep apnoea -narcolepsy -parasomnias eg sleep talking, sleep walking etc -restless leg syndrome
31
what is fatigue?
-tiredness or weariness resulting in increased difficulty sustaining a high level of performance
32
what Is excessive daytime sleepiness?
-difficulty maintaining wakefulness and an increased likelihood of falling asleep in unsuitable situation
33
what is sleep apnea?
-disorder of interrupted breathing during sleep as the airflow is blocked
34
what are the causes of sleep apnea?
- can be central ie brain signal interuption -or can be obstructive - windpipe collapse during inhalation
35
what are the symptoms & consequences of sleep apnea?
-snoring -excessive daytime sleepiness -high BP
36
what is narcolepsy?
a sleep disorder that causes people to have excessive daytime sleepiness