Congenital Infectious Disease

Question 1

What are the symptoms of congenital rubella syndrome?

Answer 1

• hearing loss
• cataracts
• hepatosplenomegaly
• thrombocytopenia (blueberry muffin skin/petechiae)
• PDA or pulmonary artery stenosis

Question 2

signs and sx of congenital CMV?

Answer 2

• SGA
• hepatosplenomegaly
• anemia
• thrombocytopenia (blueberry muffin)
• microcephaly
• cerebral atrophy
• deafness
• developmental delay
• periventricular calcification

Question 3

signs and sx of congenital herpes simplex?

Answer 3

infections happens at birth, not in utero

• primary infection: vaginal delivery within 1st week of life with sepsis and pneumonia
• recurrent infection: infection of skin, eye, or mucous membrane.

Question 4

early signs and sx of congenital syphilis?

Answer 4

1/3 of babies get hepatosplenomegaly, hepatitis, lymphadenopathy, thrombocytopenia, painful osteochondritis and periostitis, and mucocutaneous rash

Question 5

later signs and sx of congenital syphilis?

Answer 5

snuffles (rhinitis), condylomatous lesions, failure to thrive, chorioretinitis, nephritis, and Hutchinson teeth

Question 6

signs and sx of congenital toxoplasmosis?

Answer 6

1/3 babies get microcephaly, anemia, thrombocytopenia, jaundice; later will develop mental retardation, hearing loss, blindness, and severe neurologic sequelae . Intracranial calcifications scattered around cerebral cortex.

Question 7

what are the signs and sx of listeria infection in a pregnant mom?

Answer 7

flu like sx in 3rd trimester, may have eaten soft cheese or deli meat

Question 8

What are the signs and sx of listeria infection in newborn?

Answer 8

• preterm delivery
• brown amniotic fluid
• diffuse pustular rash
• respiratory failure
• sepsis

Question 9

signs and sx of group B strep and e. coli infection in newborn?

Answer 9

• temperature instability
• lethary
• poor feeding
• respiratory failure
• sepsis

Question 10

signs and sx of congenital neisseria gonorrhea infection?

Answer 10

• bilateral, purulent conjunctivitis at 2-5 days of age

Question 11

when in pregnancy is parvovirus infection dangerous to baby?

Answer 11

within the first 20 weeks

Question 12

complication of congenital parvovirus infection within the first 20 weeks?

Answer 12

hydrops fetalis

Question 13

what can happen with congenital varicella infection in utero?

Answer 13

1. 1-2% develop congenital varicella syndrome
2. 98-99% at risk for early development of zoster without previous varicella infection

Question 14

signs and sx in infant with congenital varicella syndrome?

Answer 14

• mircrocephaly
• cortical atrophy
• cataracts
• scarred skin
• muscular atrophy
• limb and digit hypoplasia