Congenital Hypothyroidism

Question 1

The butterfly-shaped organ that produces thyroid hormones.

Answer 1

Thyroid Gland

Question 2

What genetic trait is Congenital Hypothyroidism?

Answer 2

Autosomal Recessive

Question 3

What are the functions of Thyroid Gland?

Answer 3

• Normal brain development
• Development of muscles and bones
• Regulation of body temperature
• Maintain heart rate

Question 4

It determines whether the thyroid is performing properly.

Answer 4

Free thyroid hormone (FT4)

Question 5

What are the 2 types of Congenital Hypothyroidism?

Answer 5

• Thyroid Dysgenesis
• Thyroid Dyshormonogenesis

Question 6

What type of congenital hypothyroidism when the thyroid gland fails to develop or function properly?

Answer 6

Thyroid Dysgenesis

Question 7

What type of Congenital Hypothyroidism results from mutation in several genes that are involved in the production of thyroid hormones?

Answer 7

Thyroid Dyshormonogenesis

Question 8

What are the 2 genes of Thyroid Dysgenesis?

Answer 8

• Paired box gene 8 (PAX8) found in chromosome 15
• Thyroid stimulating hormone receptor (TSHR) found in chromosome 14

Question 9

What are the genes involved in Thyroid Dyshormonogenesis?

Answer 9

• Dual oxidase 2 (DUOX2) found in chromosome 15
• Solute Carrier Family 5 Member (SLC5A5) found in chromosome 19
• Thyroglobulin (TG) found in chromosome 8
• Thyroid peroxidase (TPO) found in chromosome 2

Question 10

What is the treatment for Congenital Hypothyroidism?

Answer 10

L-thyroxine tablet

Question 11

What does the L-thyroxine tablet do?

Answer 11

It provides more thyroid hormone