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Pharm 310 Immunology > Compliment > Flashcards

Compliment Flashcards

1
Q

CD40

A

receptor on B-cells that is activated by CD4 T cells to differentiate to plasma cells

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2
Q

B-cell activation

A

Ag binds BCR and is presented on MHC 2 then CD4 T2H T cell binds correct Ag and delivers CD40L to activate plasma cell differentiation

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3
Q

B-cell clonal deletion

A

if the B-cell has low affinity immunoglobulin it fails to cross link with T cell and dies

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4
Q

B-Cell differentiation

A

B-cells with high affinity Ig become memory cells or plasma cells

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5
Q

IgM secretion

A

plasma cells in bone marrow (only type released here), spleen and lymph nodes

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6
Q

FcRn (brambell receptor)

A

Transporter similar to MHC 1 molecule that transports IgG into extracellular tissue space for more coverage

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7
Q

FcRn function

A

generic endocytosis occurs where the acidic pH triggers IgG binding to FcRn and prevents proteolysis. Basic pH of extracellular fluid causes release

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8
Q

transcytosis

A

Poly-Ig receptor on basolateral surface of epithelial cells bind dimeric IgA, the secretory piece binds to IgA and mucus to prevent dissociation away from the mucus membrane

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9
Q

IgA locations

A

epithelia linings, faces, sputum, tears, breast milk

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10
Q

maternal protection

A

FcRn also allows for transport across the placenta giving baby equal amounts of IgG to mother.
IgA is transfered through breast milk during feeding

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11
Q

infant Aby production

A

IgM production starts soon after birth with IgG about 6 months later.

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12
Q

Neutralization

A

Via Aby either blocking virus receptor binding or bacterial adhesions to prevent colonization

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13
Q

opsonization

A

Aby mark bacterium for phagocytosis and death
neutrophils, monocytes and macrophages have Fc receptors specific to certain isotypes

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14
Q

IgG opsonization

A

activate macrophages, neutrophils, eosinophils and dendritic cells
cause respiratory burst to kill

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15
Q

IgE opsonization

A

Bind almost pertinently
activate mast cells, eosinophils, basophils and FDCs. cause granule secretion

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16
Q

IgA opsonization

A

activate macrophages, neutrophils and eosinophils
induce uptake to kill

17
Q

Mast cell activation

A

Via multivalent Ag crosslinks from IgE binding to Fc-epsilon-R1 receptors

18
Q

Mast cell granules

A

histamine and Inflamm soup to increase BV permeability, very fast response to Ag and targets parasites

19
Q

ADCC

A

Aby-dependent cell-mediated cytotoxicity, via Nk cells granzyme triggered apoptosis

20
Q

Natural killer cellss

A

Lymphocytes with no TCR or surface Ig, operates for innate immunity expressing Fc-gamma receptor that targets Aby coated human cells for death

21
Q

Complement production

A

Glycoproteins all synthesized in the liver, produced as inactive zymogens until cleaved

22
Q

Complement sequence

A

1,4,2,3,5,6,7,8,9
factors B,D,H,I,P
mannose binding lectin MBL

23
Q

Classical pathway

A

Ag binds antigen which opens up C1 binding sites, C1 cleaves and joins C4b which cleaves and joins C2a forming the C3 convertase to populate the surface with cleaved C3, then adds C3b to create C5 convertase to complete MAC formation

24
Q

C4b2a

A

C3 convertase for classical and lectin pathway

25
Q

C3bBb

A

C3 convertase for alternative pathway

26
Q

Alternative pathway

A

C3 auto cleaves near membranes becoming iC3 where factor B binds is cleaved by factor and creates the C3bBb C3 convertase, associates with C3b to form C5 convertase and complete MAC formation

27
Q

C1 complex

A

C1q (binds Aby hinge region) ,C1r and C1s (both cleave C proteins for activation)

28
Q

Staple form

A

IgM when it binds Ag on surface exposed hinge region for C1

29
Q

MAC complex

A

Started by cleaved C5b separate from C5 convertase. associates with other C’s and 9 comes to open the hole

30
Q

anaphylatoxin

A

Many of the “inactive” cleaved portions of C proteins act as chemoattractants to recruit more immune cells and increase BV permeability

31
Q

properdin factor

A

Stabilizes C3bBb by protecting from Factor H on surface of cell to produce lots of C3b

32
Q

DAF

A

decay accelerating factor disrupts C3bBb convertase to slow immune response

33
Q

MCP

A

Membrane Co-factor protein disrupts C3bBb convertase to slow immune response

34
Q

CR1 receptor

A

binds C3b and C4b to decay and stimulate phagocytosis of immune complexes
RBC are key for this as they are great at carrying these complexes away to liver or spleen for macrophage death

35
Q
A

Pharm 310 Immunology (7 decks)

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