Complex traits Flashcards

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1
Q

The interaction of many genes + many environmental factors is known as…

A

The multifactorial hypothesis of complex traits.

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2
Q

What visual method converts continuous data into discrete data?

A

A histogram.

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3
Q

Is variance in the original units, or squared units?

A

Squared units.

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4
Q

What type of distribution do complex traits usually follow?

A

A normal distribution.

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5
Q

When there is no dominance, gene action is…

A

Additive.

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6
Q

Define broad-sense heritability.

A

The phenotypic variance explained by genetics.

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7
Q

What measure tells us how well a trait responds to selective breeding?

A

Narrow-sense heritability.

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8
Q

Low heritability means no genetic involvement. True or false?

A

False.

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9
Q

Heritability is useful for interpreting differences between populations. True or false?

A

False.

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10
Q

What is the opposite of a complex trait?

A

A Mendelian trait.

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11
Q

What study design is commonly used to estimate broad-sense heritability?

A

Twin studies.

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12
Q

What are two reasons twin studies are not 100% valid?

A
  1. Environments cannot be randomised.
  2. Twin separation may take months or years.
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13
Q

Does higher additive gene action increase heritability?

A

Yes.

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14
Q

What term refers to the genes that contribute to a complex trait?

A

Quantitative trait loci (QTL).

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15
Q

Would a backcross of a quantitative trait show a continuous or Mendelian phenotypic range?

A

Continuous.

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16
Q

As we can’t backcross humans, what method do we use instead?

A

Association mapping.

17
Q

For QTL mapping, what could we use as genetic markers?

A

SNPs or microsatellites.

18
Q

What does Vg consist of?

A

Vg = Va + Vd + Vi (or simply Vg = Va)