Complement/interferon

Question 1

Produced by leucocytes

Answer 1

Interferon alpha

Question 2

Antiviral action - hep B, C, Kaposi’s sarcoma. Also renal cell cancer

Answer 2

Interferon alpha

Question 3

Produced by fibroblasts

Answer 3

Interferon beta

Question 4

For relapsing-remitting MS

Answer 4

Interferon beta

Question 5

Produced by natural killer cells

Answer 5

Interferon gamma

Question 6

Produced by T helper cells

Answer 6

Interferon gamma

Question 7

Activate macrophages

Answer 7

Interferon gamma

Question 8

Used in chronic granulomatous disease, osteopetrosis

Answer 8

Interferon gamma

Question 9

Deficiency causes hereditary angioedema

Answer 9

C1-INH (low during attack)

Question 10

Deficiency predisposes to immune complex disease (SLE, HSP)

Answer 10

C1q, C1rs, C2, C4

Question 11

Deficiency causes recurrent bacterial infections

Answer 11

C3

Question 12

Deficiency causes N meningitidis infection

Answer 12

C5-9

Question 13

Deficiency predisposes to Leiner disease

Answer 13

C5

Question 14

Hereditary angioedema - screening between attacks

Answer 14

C4 (also C2)

Question 15

IL-1

Answer 15

Vasodilation, mediator of shock in sepsis, pyrexia. Secreted by macrophages + monocytes.

Question 16

IL-2

Answer 16

Differentiate T cells. Inhibited by calcineurin inhibitors.