Autoantibodies Flashcards
anti-Mi-2
Specific autoantibody associated with dermatomyositis. It is found in 60% of patients who test positive for ANA.
anti-Ro
Autoantibody associated with Sjogren’s syndrome, systemic lupus erythematosus (SLE), and congenital heart block.
anti-La
Autoantibody associated with Sjogren’s syndrome.
anti-Jo 1
Autoantibody associated with polymyositis.
anti-scl-70
Autoantibody associated with diffuse cutaneous systemic sclerosis.
anti-centromere
Autoantibody associated with limited cutaneous systemic sclerosis.
Anti-MuSK
Myasthenia gravis
Anti-AChR
myasthenia gravis
Anti-VGCC
Lambert-Eaton syndrome
anti-U1 ribonucleoprotein (RNP)
Mixed connective tissue disease
Anti-GM1
Guillain-Barre (25% patients)
Anti-GQ1b
Miller-Fisher Syndrome (descending GB) 90% pts
anti-dsDNA
Highly specific SLE
anti-Smith
Highly specific SLE, 30% sensitive
Anti-phospholipase A2 antibodies
Membranous glomerulonephritis