Autoantibodies Flashcards

1
Q

anti-Mi-2

A

Specific autoantibody associated with dermatomyositis. It is found in 60% of patients who test positive for ANA.

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2
Q

anti-Ro

A

Autoantibody associated with Sjogren’s syndrome, systemic lupus erythematosus (SLE), and congenital heart block.

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3
Q

anti-La

A

Autoantibody associated with Sjogren’s syndrome.

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4
Q

anti-Jo 1

A

Autoantibody associated with polymyositis.

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5
Q

anti-scl-70

A

Autoantibody associated with diffuse cutaneous systemic sclerosis.

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6
Q

anti-centromere

A

Autoantibody associated with limited cutaneous systemic sclerosis.

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7
Q

Anti-MuSK

A

Myasthenia gravis

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8
Q

Anti-AChR

A

myasthenia gravis

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9
Q

Anti-VGCC

A

Lambert-Eaton syndrome

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10
Q

anti-U1 ribonucleoprotein (RNP)

A

Mixed connective tissue disease

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11
Q

Anti-GM1

A

Guillain-Barre (25% patients)

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12
Q

Anti-GQ1b

A

Miller-Fisher Syndrome (descending GB) 90% pts

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13
Q

anti-dsDNA

A

Highly specific SLE

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14
Q

anti-Smith

A

Highly specific SLE, 30% sensitive

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15
Q

Anti-phospholipase A2 antibodies

A

Membranous glomerulonephritis

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16
Q

Anti-liver-kidney microsomal

A

Hepatitis - type 1 autoimmune, type 2 drug induced

17
Q

Anti-Ri

A

opsoclonus-myoclonus

18
Q

Anti-cardiolipin

A

Antiphospholipid syndrome

19
Q

Anti-beta2 glycoprotein I

A

Antiphospholipid syndrome