Common Pathologies in pregnancy 2

Question 1

What is TOPFA?

Answer 1

Termination of pregnancy for abnormality

Question 2

What are the effects of too much glucose in the mother?

Answer 2

Baby’s insulin rises
Baby’s glucose cannot fall as mother keeps sending more glucose
Longterm high insulin and glucose = big baby

Question 3

What are the risks of maternal diabetes?

Answer 3

Malformations
SGA babies
Intrauterine death
Neonatal hypoglycaemia

Question 4

What is Chorioamnionitis?

Answer 4

Acute inflammation

Neutrophils present in membranes, cord and fetal plate

Question 5

What is Acute Chorioamnionitis?

Answer 5

Ascending infection by perineal or perianal flora which ascend vagina and get into the amniotic sac

Question 6

How does ascending infection present?

Answer 6

Mother ill or not depends on whether raised neutrophils in blood
Intrauterine death
Cerebral palsy later in life

Question 7

How does ascending infection affect baby’s brain?

Answer 7

Neutrophils produce cytokine storm which activates brain cells and damaged by normal labour hypoxia

Question 8

Do opiates cross the placenta?

Answer 8

Yes

Question 9

What is abruption?

Answer 9

Separation of placenta and uterine wall
Hypoxia in baby
Antepartum haemorrhage

Question 10

What are the causes of abruption?

Answer 10

Hypertension
Trauma
Cocaine