Common drugs in IBD

Question 1

Aminosalicylates Name

Answer 1

Balsalazide (prodrug of 5ASA)
Olsalazine Diner of 5ASA
Mesalazine(5asa)
Sulfasalazine (5ASA and sulfpyride carrier)

Question 2

Corticosteroid

Answer 2

Pred , methyl pred, hydrocortisone , beclometasone (used in mild mod uC)

Question 3

Drugs affecting immune system

Answer 3

Ciclosporin
Tacrolimus
Azathioprine
Mercaptopurine
MTX

Question 4

Aminosalicylate MOA

Answer 4

Not understood but to reduce free radical formation and cytokines and inhibit prostaglandin synthesis

Question 5

S/e aminosalicylates

Answer 5

Blood dyscrasias (counsel)
Nephrotoxic
Salicylate hypersensitivity (hives or itch)
Yellow/orange stains bodily fluid and soft contacts

Question 6

What colour do aminosalicylates colour contacts

Answer 6

Yellow/orange

Question 7

Interaction of aminosalicylates

Answer 7

Mesalazine interact with Lactulose as it lowers ph preventing release of active in e/c and m/r prep