Combination GLP-1–Insulin Therapy.

Question 1

What are the two fixed-ratio combinations of GLP-1 RA with basal insulin analogs?

Answer 1

Insulin degludec plus liraglutide (IDegLira) and insulin glargine plus lixisenatide (iGlarLixi).

Question 2

Describe the glycemic lowering efficacy of the combination of basal insulin with GLP-1 RA compared to the monocomponents.

Answer 2

The combination of basal insulin with GLP-1 RA results in greater glycemic lowering efficacy than the monocomponents.

Question 3

What are the benefits of using a fixed-ratio combination of basal insulin and GLP-1 RA compared to intensified insulin regimens?

Answer 3

The fixed-ratio combination has less weight gain and lower rates of hypoglycemia than intensified insulin regimens.

Question 4

How does a fixed-ratio combination of basal insulin and GLP-1 RA compare to GLP-1 RA alone in terms of gastrointestinal tolerability?

Answer 4

The fixed-ratio combination has better gastrointestinal tolerability than GLP-1 RA alone.

Question 5

In studies of people with type 2 diabetes inadequately controlled on basal insulin or GLP-1 RA, what were the results of switching to a fixed-ratio combination of basal insulin and GLP-1 RA?

Answer 5

Switching to a fixed-ratio combination demonstrated significant improvements in blood glucose levels and achievement of glycemic goals with fewer hypoglycemic events than with basal insulin alone.