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B4 Anatomy > Collagen And The Eye > Flashcards

Collagen And The Eye Flashcards

1
Q

4 types of embryonic CT

A

Mesenchymal

Mucous

Supporting

Hematopoietic Tissue (blood and bone marrow)

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2
Q

What is a fixed cell? Ex?

A

Cells that are made and reside in the same tissue.

Fibroblasts, they’re made and reside in the CT

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3
Q

What is a wandering cell? Ex?

A

Cells that are not fixed to their tissue and they travel.

Eosinophils, mast cells, and plasma cells (derived from B-lymphocytes)

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4
Q

What do fibroblasts produce?

A

Procollagen

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5
Q

Found in connective tissue and are flexible/have a high tensile strength

A

Collagen fibers

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6
Q

Collagen structure

A

Procollagen single strands combine to make a triple helix (collagen fibril), then collagen fibrils combine to make a collagen fiber

Its tensile strength is greater than steel!

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7
Q

How many types of collagen are recognized in humans?

A

16

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8
Q

Which type of collagen makes up 90% of collagen in the body?

A

Type 1

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9
Q

3 catergoes of collagen

A

Fibrous

Non-fibrous

Filamentous

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10
Q

Collagen that is seen in an electron microscope as thick fibers

Ranges from 200 nm in skin/tendon to 25 nm in cornea

A

Fibrous collagen

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11
Q

Range of fiber size in the cornea

A

25-30 nm

Uniform

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12
Q

Variable fiber size in the skin

A

20 to 200 nm

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13
Q

Groups of collagen in the skin/cornea

A

Genetic types I, II, III collagens

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14
Q

Collagen that forms the thin basement membranes separating the fibrous stromatolites tissue from the cells

A

Non-fibrous collagen

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15
Q

Size and location of non-fibrous collagen

A

25 nm in capillaries and golmeruli

200 nm in the lens

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16
Q

What is the only catergory of collagen to be found in non-fibrous collagen?

A

Type IV collagen

IN ALL BASEMENT MEMBRANES

17
Q

Collagens that form loosely aggregates fibers with little of no periodicity

A

Filamentous collagen

18
Q

Filamentous collagen can be subdivided into what? And what types are included?

A

Pericellular and matrix collagen

Types VI, VII, IX, and X

19
Q

Collagens of the Cornea

A

Transparent tissue containing fine collagen fibers of UNIFORM diameter with a high degree of spatial organization

20
Q

Collagens of the Sclera

A

Opaque tissue containing thick interwoven collagen fibers

Structural, strength and resilience due to interlacing collagen fibers

30 nm - 300 nm

Mainly type 1 and some type III

21
Q

Collagen of the Vitreous body

A

Polysaccharide gel containing small amounts of fine collagen fibers

7-13 nm

Embedded in a hyaluronate gel

Function to stabilize shape of gel and reduce compressibility

Mainly type II collagen

22
Q

Collagen of the retina

A

Typical thin basement membrane

Non-fibrous

Bruch’s membrane

Type IV

23
Q

Collagen of the choroid

A

Highly vascularized tissue of the iris…?

24
Q

The human cornea contains __% collagen

A

90

25
Q

Vitreous body contains both:

A

Collagen fibers and elastic fibers

For maintenance of a) intraocular pressure and b) acting as a shock absorber

26
Q

What type of collagen is in the lens capsule?

A

Type IV

non-fibrous

27
Q

Membrane located under the corneal stroma, that separated the corneal stroma from the corneal epithelium

Consists of what 2 types?

A

Descemet’s membrane

90% type IV and 10% type V

28
Q

Type VI collagen is found where

A

Extra cellular matrix of the cornea

Throughout the corneal stroma

29
Q

Where is type VIII found?

A

Descemet’s membrane

Synthesized by the corneal endothelial cells

30
Q

The vitreous body contains a lot of what type?

A

Type IX

Filamentous, but has same cross-linking as fibrous

31
Q

When the cornea bulges, due to problems with the collagen

A

Keratoconus

32
Q

Collagen is important in the cornea because..

A

It plays an important role in the transparency

33
Q

The corneal strength relies on:

A

The head-to-tail orientation

Cross linking

More linking, stronger the tissue

34
Q

When the need to strengthen the cornea arises, what procedure is done?

A

Corneal Cross Linking

B4 Anatomy (10 decks)

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