Coeliac disease Flashcards
Type of inflammatory disease in coeliac disease
T-cell mediated autoimmune
Repeated exposure to trigger and reaction leads to two things in coeliac disease
- villus atrophy
- crypt hypertrophy
Protein trigger in coeliac
Gluten (gliadin)
Coeliac leads to what type of bowel dysfunction
Malabsorption
Affected area of bowel in coeliac
Jejunum
Autoantibodies in coeliac
- anti-TTG
- anti-EMA
- anti-DGPs
All new cases of what endocrine disease are tested for coeliac due to their close association
T1DM
3 autoimmune diseases associated with coeliac
- dermatitis herpetiformis
- graves
- autoimmune hepatitis
Age distribution in coeliac
Bimodal
Two alleles linked to coeliac in families where the disease runs
- HLA-DQ2
- HLA-DQ8
Is coeliac more common in males or females
Female
Coeliac symptoms
- abdominal pain
- diarrhoea
- N/V
- abdo distension
- fatigue
- weight loss
- failure to thrive
- mouth ulcers
- neurological symptoms
what two things are found in endoscopy
- villus atrophy
- crypt hypertrophy
Stool is analysed in coeliac to
Exclude infections
FBC in coeliac shows
Anaemia
Antibodies tested for in coeliac
- Anti-TTG IgA
- total IgA
- anti-EMA
Mx
Gluten free
Symptoms of the complication of patchy-associated T cell lymphoma
- weight loss
- diarrhoea
- abdo pain
Explain the microcytic and macrocytic anaemia in coeliac (& large RWD)
Lack of absorption of iron, B12, folate
Explain the bleeding in coeliac
Reduced vitK absorption
when should patients with coeliac take gluten
before diagnostic procedure
