Coagulation Process

Question 1

Hemostasis

Answer 1

Stopping of blood loss from damage blood vessels

Question 2

Coagulation

Answer 2

Blood loss stopped

-process of turning liquid blood into semisolid clot

Question 3

Clot

Answer 3

Composed of platelets and red blood cells held together by protein- fibrin

Question 4

Fibrin

Answer 4

Protein holds platelets and red blood cell together

Question 5

Hemostatic process

Answer 5

• vasoconstriction: narrowing of blood vessel that slow blood flow
• formation of platelet plug (hemostatic plug): temporary mass formed when platelet stick to each other (platelet aggregation)
• secondary plug: fibrin, longer lasting, more stable
• fibrinolysis-disintegration of blood clot

Question 6

Clotting factors

Answer 6

Process of coagulation, complex cascade of reaction involve proteins

• platelet aggregation is initiate by exposure to von willebrand factor and tissue factor
• during coagulation: protein fibrinogen is converted to fibrin by enzyme thrombin
• prothrombin: precursor to thrombin
• hemophilia: caused by deficiency of factor VIII or factor IX

Question 7

Fibrinogen

Answer 7

Factor I

-protein converted to fibrin

Question 8

Thrombin

Answer 8

Factor IIa

-enzyme

Question 9

Prothrombin

Answer 9

Factor II

-precursor to thrombin

Question 10

Hemophilia

Answer 10

Caused by deficiency of factor VIII or factor IX