Coagulation And Thrombocytes Flashcards
Stages of platelet hematopoiesis?
Megakaryoblast, promegakaryocyte, megakaryocyte, platelet
Made of lit pink cytoplasm and distinct purple granules
Platelets
Large platelets (immature)
Macro platelets
Three main functions of platelets?
Clotting, preserve capillary walls, transport substances for clotting, and for constriction and dilation of blood vessels
Are platelets larger or smaller than RBCs?
Smaller
Platelets in ______ vary in size, shape and clumping
Cats
Platelets in _____ are relatively uniform in size.
Dogs
Macro platelets are normal in….
Cats
What do macro platelets indicate in dogs?
Increased platelet use and a need for increased platelet production
Normal platelet value for dogs.
150,000 plts/uL - 450,000 plts/uL
Normal platelet values for cats.
200,000 plts/uL- 600,000 plts/uL
Variation in the size of platelets.
Pleomorphic
Cannot stop bleeding at this platelet count number.
50,000 plts/uL
Increased of platelets.
Thrombocytosis
Two causes of Thrombocytosis?
Injury/trauma/infection or steroids/splenectomy
Decrease in number of platelets.
Thrombocytopenia
Three main causes of thrombocytopenia?
Hormone disorder, disorders of platelet distribution, vitamin b12 injection
Method one of platelet count.
Viewing 10 fields, averaging the fields and reporting them.
Normal platelet per field?
7-10 platelets/hpf
Method two ***** of platelet count?
Count and record in ten fields, average them, and times by 15,000 = platelets per microliter
Cannot accurately count_____ platelets.
Clumped
Small pinpoint hemorrhages.
Pettichia
Blotches of hemmorage (usually abdomen)
Echymosis
Visible bleeding.
Frank
Hidden bleeding,
Occult bleeding
Large amounts of blood
Profuse bleeding
Steps of clotting?
- Platelets plug, 2. Clotting factors reinforce plug, 3. Fibrin web acts like glue, 4. Other cells reinforce web
Extrinsic
PT
Intrinsic
PTT
Five sizes/types of platelets?
Macro platelets, micro platelets, increased platelets, decreased platelets, clumped platelets
Platelets size of a red cell.
Macro platelet
The glue.
Fibrin
What do you have to do when you see clumped fibrin?
Send the sample out
Which organ produces the most clotting factors?
Liver
