Coagulation Flashcards
open blood vessel,
blood can rushed out of the blood vessel leading to blood loss leading to
Hypovolemia and hypovolemic shock
The body’s innate mechanism
Coagulation
refers to the sequence or stages of normal blood clotting event
Coagulated cascade
Steps in coagulation
1 vasoconstriction
2 platelet clot
the insoluble protein that can be produce from fibrinogen that will form a mesh
Fibrin
It will form again a strong a mesh, very strong network
Fibrin strand
2 major components of blood clot
Platelet
Fibrin
So kapag marami tayong fibrin, nagdidikit-dikit sila to form a fibrin strand. And that is what we call
Homeostasis
They are the first responders after chemical releases
Blood platelets
Once na nagkaroon na ng fibrin, so
ayan na yung tinatawag nating
Secondary hemostasis
it is
activated when negatively charged surfaces in contact with the blood activates factor XII, and activated platelets convert factor XI.
Intrinsic factor
activated when damaged vascular tissue releases tissue thromboplastin.
Extrinsic pathway
With its partner, Factor Va, Factor Xa converts prothrombin (II) to
thrombin (IIa)
responsible for cleaving fibrinogen forming fibrin monomers.
Thrombin (lla)
Factor responsible for covalently bonding fibrin strands together.
Factor 13