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NMSP Exam 3 > CNS Stimulant Drugs > Flashcards

CNS Stimulant Drugs Flashcards

1
Q

MOA of stimulants

A

direct and indirect non-catecholamine sympathomimetics via:

  1. block presynaptic reuptake
  2. interference with vesicular monoamine transporter (VMAT)
  3. increase NE, DA and 5HT release
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2
Q

specific MOA of methylphenidate

A

inhibition of DA reuptake and pre-synaptic reuptake

does not stimulate the release of neurotransmitters

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3
Q

common side effects of stimulants

A 
GI distress
HA
anorexia
insomnia
anxiety
irritability
elevated BP/HR
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4
Q

rare side effects of stimulants

A 
priapism
seizures
sudden cardiac death
stroke and MI
chemical leukoderma (patches only)
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5
Q

when should stimulants not be given?

A 
CV disease
anxiety
HTN
glaucoma
motor tics
bipolar disorder/psychoses
seizures/epilepsy
history of drug absue
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6
Q

are stimulants considered controlled substances?

A

yes - given in one-month supplies only

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7
Q

IR amphetamine-based stimulants

A

dextroamphetamine/AMP (Adderall)
dextroamphetamine sulfate (ProCentra)
amphetamine sulfate (Evekeo)
dextroamphetamine (Zenzidi)

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8
Q

only liquid form of IR amphetamine-based stimulant

A

dextroamphetamine sulfate (ProCentra)

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9
Q

ER amphetamine-based stimulants

A 
dextroamphetamine ER (Adderall)
dextroamphetamine (Dexedrine)
amphetamine ER (Dyanavel) 
lisdexamfetamine (Vyvanse)
amphetamine (Mydayis)
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10
Q

only liquid form of ER amphetamine-based stimulant

A

amphetamine ER (Dyanavel)

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11
Q

IR methylphenidate-based stimulants

A

dexmethylphenidate (Focalin)

methylphenidate (Methylin/Ritalin)

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12
Q

only liquid form of IR methylphenidate-based stimulants

A

methylphenidate (Methylin)

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13
Q

sustained-release methylphenidate-based stimulants

A 
methylphenidate SR (Ritalin)
methamphetamine (Desoxyn)
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14
Q

ER methylphenidate-based stimulants

A

there’s a shit ton

just know they all have methylphenidate in generic name

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15
Q

transdermal patch for ER methylphenidate-based stimulants

A

Daytrana

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16
Q

chewable tablet for ER methylphenidate-based stimulants

A

Quillichew

17
Q

liquid form for ER methylphenidate-based stimulants

A

Quillivant XR

18
Q

what are the nonstimulants used for ADHD?

A

atomoxetine
guanfacine
clonidine

19
Q

MOA of atomoxetine

A

inhibition of NE pre-synaptic reuptake

20
Q

MOA of guanfacine and clonidine

A

a2 adrenergic agonists

modulate noradrenergic tone in PFC by enhanced noradrenergic input from the locus crecelius

NMSP Exam 3 (18 decks)

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