Clinical Approach to Mood Disorders Flashcards
What is the most common psychiatric illness?
Depression
Higher in females
What happens to NE, Dopamine, 5-HT, and GABA in Major Depressive DO?
All decreased
What is the diagnostic criteria for MDD?
5 of the following for 2 weeks without any manic, hypomanic, or mixed episodes:
- Depressed mood
- Decreased interest in normal activities
- Weight Loss/Gain
- Insomnia
- Agitation/Retardation (slow throughout the day)
- Fatigue
- Worthlessness
- Can’t concentrate
- Thoughts of death and suicide
Examples of treatment for MDD
TCAs MAOi SSRI's Trazodone Bupropion
What is Electroconvulsive Therapy?
Used for treatment-resistant depression
Series of shocks to the brain induce seizures to help “reset” patient.
Ketamine therapy for MDD
NMDA antagonist administered over a 45-60m infusion for treatment-resistant depression
Persistent Depressive Disorder (Dysthymia)
Depressed mood for at least 2 years in adults (1y in children) that is not severe enough to be MDD.
Cannot have withdrawal of symptoms for >2m
Depression with Seasonal Pattern (aka Seasonal Affective Disorder)
onset and remission of major depressive episodes that correspond with times of the year.
Symptoms of “Hibernation”- eating more and sleeping more
Tx: Light Therapy
Premenstrual Dysphoric Disorder (PMDD)
Mood instability the week before menses (cough.. Allison)
Tx: Exercise, Diet, Relaxation
What is defined as a manic episode?
Elevated, Expansive, or irritable mood for >1w and 3 of the following: Inflated Self-Esteem Decreased need for sleep Pressured Speech Racing thoughts Goal-oriented behavior Excessive pleasurable activities (sex)
Hypomanic Episode
Less severe and shorter time than a manic episode. Usually only 4 days and no psychotic features.
Not bad enough for mania, but bad enough for people to notice.
Bipolar I Disorder
A single Severe manic episode can be diagnostic. Major depressive episode not required as in Type II, but can be present.
Bipolar II Disorder
At least 1 depressive and 1 hypomanic episode. Tends to be more hypomania than full blown manic. More prevalent
2 mood stabilizing treatments that are 1st line for Bipolar Disorder
Lithium
Valproic Acid
Cyclothymic Disorder
Lesser form of Bipolar similar to Persistent Depressive Disorder. Patients have hypomanic and depressive periods over 2 years but do not meet criteria for BP.
Tx: Same as BP