Alcohol, Caffeine, and Drugs of Abuse Flashcards

1
Q

abstinence syndrome

A

the signs and symptoms that occur on withdrawal of a drug in a dependent person

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2
Q

addiction

A

compulsive drug-using behavior in which the person uses the drug for personal satisfaction, often in the face of know risk to health

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3
Q

controlled substance

A

a drug deemed to have abuse liability that is listed on govt schedules of controlled substances

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4
Q

dependence

A

a state characterized by signs and symptoms when it is withdrawn from chronic use or when the dose is abruptly lowered

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5
Q

designer drug

A

a synthetic derivative of a drug with slightly modified structure

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6
Q

tolerance

A

a decreased response to a drug, necessitating larger doses to achieve the same effect

metabolic, behavioral or functional tolerance

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7
Q

sensitization

A

an increased response with repetition of the same dose of a drug

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8
Q

withdrawal

A

adaptive changes that become fully apparent once drug exposure is terminated

*evidence of physical dependence

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9
Q

schedule 1 drugs

A

no medical use
high addiction potential

ex: heroin

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10
Q

schedule 2 drugs

A

medical use
high addiction potential

ex: amphetamines

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11
Q

schedule 3 drugs

A

medical use
moderate abuse potential

ex: anabolic steroids

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12
Q

schedule 4 drugs

A

medical use
low abuse potential

ex: benzos

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13
Q

what are considered the drugs of abuse?

A
alcohol
tobacco
marijuana
inhalants
stimulants
depressants
hallucinogens
narcotics
PCP
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14
Q

most commonly abused painkillers

A

fentanyl
hydrocodone
oxycodone

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15
Q

most commonly abused depressants

A

alprazolam
zolpidem
zaleplon

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16
Q

most commonly abused stimulants

A

adderal

methylphenidate

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17
Q

stimulant overdose sx

A
agitation
HTN
tachy
delusions
hallucinations
hyperthermia
seizures
death
18
Q

stimulant withdrawal sx

A
apathy
irritability
increased sleep
disorientation
depression
19
Q

barbiturate, benzo and alcohol overdose sx

A
slurred speech
drunken behavior
dilated pupils
weak, rapid pulse
clammy skin
shallow resp
coma
death
20
Q

barbiturate, benzo and alcohol withdrawal sx

A
anxiety
insomnia
delirium
tremors
seizures
death
21
Q

opioid overdose sx

A
constricted pupils
clammy skin
nausea
drowsiness
resp depression
coma
death
22
Q

opioid withdrawal sx

A
nausea
chills
cramps
lacrimation
rhinorrhea
yawning
hyperpnea
tremor
23
Q

opioid receptor antagonists

A

naloxone (narcan)

naltrexone

24
Q

synthetic opioid

25
partial µ-opioid receptor agonist
buprenorphine
26
nicotinic receptor partial agonist
varenicline (chantix)
27
NMDA receptor antagonist
acamprosate *reduces desire to drink alcohol
28
drugs of abuse that are not necessarily addictive
``` LSD mescaline psilocybin PCP ketamine ```
29
medical uses for caffeine
``` improve mental alertness migraines post-epidural headaches asthma ADHD memory ```
30
alcohol metabolism timeline
1 ounce of alcohol takes 1 hour to metabolize
31
binge drinking for women
4 or more drinks during a single occasion
32
binge drinking for men
5 or more drinks during a single occasion
33
heavy drinking for women
8 or more drinks per week
34
heavy drinking for men
15 or more drinks per week
35
explain the metabolism of alcohol
undergoes first-pass metabolism by gastric and liver alcohol dehydrogenase and aldehyde dehydrogenase follows zero order kinetics
36
tx for acute alcohol intoxication
monitor respiratory depression and aspiration glucose to treat metabolic alterations thiamine to protect against Wernicke-korsakoff
37
tx for acute withdrawal syndrome
major pharm objective is to prevent seizures, delirium, arrhythmias electrolyte rebalancing, and thiamine therapy benzos
38
what drugs can be used for prevention of alcohol abuse
acamprosate disulfiram naltrexone
39
what drugs can be used for acute methanol or ethylene glycol poisoning
ethanol | fomepizole
40
disulfiram
inhibits aldehyde dehydrogenase and causes extreme discomfort in patients who drink alcohol
41
fomepizole
inhibits alcohol dehydrogenase